BioMed Research International

Cardiac Proteomics


Publishing date
02 May 2014
Status
Published
Submission deadline
13 Dec 2013

1Research Institute for Sport 8 Exercise Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK

2Department of Physiology 8 Biophysics, University of Illinois at Chicago, Chicago, IL 60612-7342, USA


Cardiac Proteomics

Description

The functional capacity of the heart is dictated by its proteome, and in recent years exciting discoveries have linked proteome data, in particular covalent protein modifications, with important aspects of cardiac function. Continuing advances in technology, instrumentation, and the sophistication of proteomics studies promises yet greater understanding and the generation of new biomarkers and therapeutic targets for cardiac diseases. Cardiomyopathy may occur due to inherited or environmental factors and is a progressive process that often coincides with other complicated risk factors such as low exercise capacity, hypertension, and dyslipidaemia. Therefore, understanding the deterioration of cardiac performance is a particularly challenging area of research.

We warmly invite investigators to contribute original research articles and review articles that enhance understanding of cardiomyopathy or the protective effects of interventions including exercise and dietary manipulations. We are particularly interested in articles that characterise posttranslational modifications in the context of physiological growth or pathophysiological cardiac hypertrophy and reports of new technologies or methods for studying protein modification. Profiling of new models relevant to this field will also be of interest, as well as functional proteomic studies assessing the impact of manipulating protein targets in model systems. Ultimately, we aim for this special issue to serve as a point of reference for burgeoning themes in cardiac proteomics. Potential topics include, but are not limited to:

  • Proteomic analysis of models of cardiomyopathy or cardioprotection
  • Proteomic analysis of cardiac development and cardiomyocyte differentiation
  • Proteomic characterisation of human explant samples
  • Novel protein biomarkers in cardiovascular disease
  • Characterisation of protein species using 2D electrophoresis and mass spectrometry
  • Technologies for the enrichment and characterisation of modified peptides
  • Mass spectrometry characterisation of protein species using top-down, middle-down, or bottom-up approaches
  • Bioinformatic tools specific to the interrogation of proteomics data
  • Proteomic analysis of manipulating protein targets model systems
  • Targeted mass spectrometry approaches for monitoring modified proteins

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/cardiology/prot/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 903538
  • - Editorial

Cardiac Proteomics

Jatin G. Burniston | Anthony O. Gramolini | R. John Solaro
  • Special Issue
  • - Volume 2014
  • - Article ID 634132
  • - Review Article

Effects of Hypertension and Exercise on Cardiac Proteome Remodelling

Bernardo A. Petriz | Octavio L. Franco
  • Special Issue
  • - Volume 2014
  • - Article ID 942718
  • - Research Article

Analysis of Pericardial Effusion from Idiopathic Pericarditis Patients by Two-Dimensional Gel Electrophoresis

Sadan Yavuz | Murat Kasap | ... | Turan Berki
  • Special Issue
  • - Volume 2014
  • - Article ID 767812
  • - Research Article

Cardiac Phosphoproteomics during Remote Ischemic Preconditioning: A Role for the Sarcomeric Z-Disk Proteins

Safa Abdul-Ghani | Kate J. Heesom | ... | M-Saadeh Suleiman
  • Special Issue
  • - Volume 2014
  • - Article ID 810562
  • - Research Article

Age and SPARC Change the Extracellular Matrix Composition of the Left Ventricle

Lisandra E. de Castro Brás | Hiroe Toba | ... | Amy D. Bradshaw
  • Special Issue
  • - Volume 2014
  • - Article ID 246195
  • - Review Article

Proteomic Profiling of the Dystrophin-Deficient mdx Phenocopy of Dystrophinopathy-Associated Cardiomyopathy

Ashling Holland | Kay Ohlendieck
  • Special Issue
  • - Volume 2014
  • - Article ID 151726
  • - Research Article

Comparison of the Ventricle Muscle Proteome between Patients with Rheumatic Heart Disease and Controls with Mitral Valve Prolapse: HSP 60 May Be a Specific Protein in RHD

Dawei Zheng | Limin Xu | ... | Yiming Ni
BioMed Research International
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Acceptance rate31%
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CiteScore3.600
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