BioMed Research International

Integrated Analysis of Multiscale Large-Scale Biological Data for Investigating Human Disease


Publishing date
16 Jan 2015
Status
Published
Submission deadline
29 Aug 2014

Lead Editor

1Mount Sinai School of Medicine, New York, USA

2Shanghai Maritime University, Shanghai, China

3Chinese Academy of Sciences, Shanghai, China

4Monash University, Clayton, Australia


Integrated Analysis of Multiscale Large-Scale Biological Data for Investigating Human Disease

Description

Integrating large-scale data obtained from multiscales is essential for understanding the molecular basis of complex diseases and providing useful therapeutic targets. Several large projects, such as The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Genotype-Tissue Expression (GTEx), and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), have measured the somatic mutation, copy number variation (CNV), mRNA expression, microRNA expression, and methylation data and made them publicly available. Recently, many statistical methods and analysis tools have been developed based on these multiscale large-scale data. A special issue of research or review articles in these research fields is important and timely. The potential contributors for the special issue are oncologist, computational biologists, mathematical biologists, bioinformaticians, systems biologists, and computational pharmacist. We invite authors to contribute original research articles as well as review articles to this special issue.

Potential topics include, but are not limited to:

  • Subtype stratification of patients
  • Multiscale network construction
  • Network module identification
  • Predictive model of disease state
  • Biomarker discovery
  • Combinatorial drug discovery
  • Translational medicine
  • Novel computational methods in large biology data analysis
  • Inferring gene function from expression data
  • Inferring gene function from genome sequence data
  • Integrating expression data with other genome-wide data for functional annotation
  • Integrating expression data from different organisms

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 760765
  • - Editorial

Integrated Analysis of Multiscale Large-Scale Biological Data for Investigating Human Disease

Tao Huang | Lei Chen | ... | Jiangning Song
  • Special Issue
  • - Volume 2015
  • - Article ID 890381
  • - Research Article

Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network

Yongcheng Dong | Qifan Kuang | ... | Menglong Li
  • Special Issue
  • - Volume 2015
  • - Article ID 746970
  • - Research Article

Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling

Dongguo Li | Hong Xia | ... | Lin Li
  • Special Issue
  • - Volume 2015
  • - Article ID 301635
  • - Research Article

A Network Flow Approach to Predict Protein Targets and Flavonoid Backbones to Treat Respiratory Syncytial Virus Infection

José Eduardo Vargas | Renato Puga | ... | Renato Tetelbom Stein
  • Special Issue
  • - Volume 2015
  • - Article ID 964795
  • - Research Article

Identification of Novel Thyroid Cancer-Related Genes and Chemicals Using Shortest Path Algorithm

Yang Jiang | Peiwei Zhang | ... | Yu-Fei Gao
  • Special Issue
  • - Volume 2015
  • - Article ID 707453
  • - Research Article

Probabilistic Inference of Biological Networks via Data Integration

Mark F. Rogers | Colin Campbell | Yiming Ying
  • Special Issue
  • - Volume 2015
  • - Article ID 576349
  • - Research Article

A Meta-Analysis Strategy for Gene Prioritization Using Gene Expression, SNP Genotype, and eQTL Data

Jingmin Che | Miyoung Shin
  • Special Issue
  • - Volume 2015
  • - Article ID 394260
  • - Research Article

The Construction of Common and Specific Significance Subnetworks of Alzheimer’s Disease from Multiple Brain Regions

Wei Kong | Xiaoyang Mou | ... | Yang Yang
  • Special Issue
  • - Volume 2015
  • - Article ID 501262
  • - Research Article

Identification of Subtype Specific miRNA-mRNA Functional Regulatory Modules in Matched miRNA-mRNA Expression Data: Multiple Myeloma as a Case

Yunpeng Zhang | Wei Liu | ... | Xia Li
  • Special Issue
  • - Volume 2014
  • - Article ID 598129
  • - Research Article

Large-Scale Protein-Protein Interactions Detection by Integrating Big Biosensing Data with Computational Model

Zhu-Hong You | Shuai Li | ... | Zhen Ji
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.