BioMed Research International

Clot Structure and Fibrinolysis in Thrombosis and Hemostasis


Status
Published

Lead Editor

1University of Debrecen, Debrecen, Hungary

2University of Leeds, Leeds, UK

3Erasmus University Medical Center, Rotterdam, Netherlands

4North-West University, Potchefstroom, South Africa

5University of North Carolina, Chapel Hill, USA


Clot Structure and Fibrinolysis in Thrombosis and Hemostasis

Description

Studying the structural features of the blood clot and its consequences on medical disorders is an expanding area in coagulation research. The conversion of fibrinogen to fibrin and its cross-linking by activated factor XIII represent the final steps in blood coagulation required to form a stable clot. There is a fine balance between clot formation and fibrinolysis determining clot stability. Moreover, as clot formation in vivo occurs in a complex environment, whole blood clots contain cellular elements which greatly influence thrombus size, composition, and stability. One of the great advances in the last decade was the discovery of neutrophil extracellular traps (NETs), which are now known to influence clot formation and the lytic and mechanical stability of clots. The structural, biological, physical, and chemical properties of the blood clot may vary considerably depending on genetic and environmental factors. Altered fibrin structure and affected fibrinolysis have been linked to several diseases, including cardiovascular diseases, such as myocardial infarction, ischemic stroke, or venous thromboembolism. On the other hand, specific changes in the fibrin clot structure might lead to diseases associated with a bleeding phenotype. Altered levels of hemostatic and fibrinolytic proteins have been found in various chronic diseases associated with vascular complications, for example, chronic liver disease, diabetes mellitus, systemic autoimmune disorders, chronic kidney failure, atrial fibrillation, and Alzheimer disease. Recent research revealed important new genetic and acquired factors affecting thrombus formation, clot structure, and fibrinolysis.

The aim of this special issue is to present and discuss recent progress in the research of blood clot formation, structure, fibrinolysis, and possible clinical consequences. High-quality original research papers as well as review articles are solicited. Submitting basic scientific, translational, or clinical papers contributing to the advances in these fields all is encouraged.

Potential topics include but are not limited to the following:

  • Basic studies on fibrin clot/whole blood clot properties
  • Basic studies on fibrinolysis
  • Neutrophil extracellular traps and clot structure/fibrinolysis
  • Clot structure and fibrinolysis in thrombotic/bleeding disorders
  • Clot structure and fibrinolysis in various diseases
  • Animal models on clot formation, thrombosis, and fibrinolysis
  • Clinical studies on genetic or environmental factors associated with clot formation/fibrinolysis
  • New methods or models in the field of clot structure/fibrinolysis research

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 4645137
  • - Editorial

Clot Structure and Fibrinolysis in Thrombosis and Hemostasis

Zsuzsa Bagoly | Robert A. S. Ariëns | ... | Alisa S. Wolberg
  • Special Issue
  • - Volume 2017
  • - Article ID 6385628
  • - Research Article

Nonuniform Internal Structure of Fibrin Fibers: Protein Density and Bond Density Strongly Decrease with Increasing Diameter

Wei Li | Justin Sigley | ... | Martin Guthold
  • Special Issue
  • - Volume 2017
  • - Article ID 3571861
  • - Review Article

Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment

Lilla Paragh | Daniel Törőcsik
  • Special Issue
  • - Volume 2017
  • - Article ID 1209676
  • - Review Article

Inhibition of Fibrinolysis by Coagulation Factor XIII

Dingeman C. Rijken | Shirley Uitte de Willige
  • Special Issue
  • - Volume 2017
  • - Article ID 5130495
  • - Research Article

Structure and Function of Trypsin-Loaded Fibrinolytic Liposomes

Anna Tanka-Salamon | Attila Bóta | ... | Krasimir Kolev
  • Special Issue
  • - Volume 2017
  • - Article ID 8196256
  • - Review Article

Prothrombotic Fibrin Clot Phenotype in Patients with Deep Vein Thrombosis and Pulmonary Embolism: A New Risk Factor for Recurrence

Anetta Undas
  • Special Issue
  • - Volume 2017
  • - Article ID 3678017
  • - Research Article

Intracardiac Hemostasis and Fibrinolysis Parameters in Patients with Atrial Fibrillation

Noémi Klára Tóth | Zoltán Csanádi | ... | Zsuzsa Bagoly
  • Special Issue
  • - Volume 2017
  • - Article ID 9876819
  • - Research Article

Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera

Sara C. Meyer | Eva Steinmann | ... | Dimitrios A. Tsakiris
  • Special Issue
  • - Volume 2017
  • - Article ID 9795271
  • - Research Article

The Phosphatase Inhibitor Calyculin-A Impairs Clot Retraction, Platelet Activation, and Thrombin Generation

Renáta Hudák | János Vincze | ... | János Kappelmayer
  • Special Issue
  • - Volume 2017
  • - Article ID 6138145
  • - Review Article

The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression

János Kappelmayer | Béla Nagy
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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