Recently, there have been many changes in the assessment and management of pain. The way we use sedation in children has also been modified. There is a greater sensitivity when looking at the side effects of pain. Monitoring the sedation and analgesia status in sick children following a protocol needs to be applied. Various clinical scales and objective methods have been developed to carry out this task.

New drugs like dexmedetomidine and new routes of administration (e.g., inhalation or intranasal route) are now used for procedures. Some studies have analyzed the effects of excessive sedation and deprivation when withdrawing sedative and analgesic drugs in children. Potential secondary effects on neurodevelopment have been suggested.

The aim of this Special Issue is to collect original research articles and review articles about sedation and analgesia. Research can occur at various pediatric ages (from neonate to adolescent). Different situations can also be described (e.g., analgesia and sedation with procedures, analgesia for conical pain and sedoanalgesia in children needing pediatric intensive care). Studies on the incidence and prophylaxis of drug withdrawal in clinical settings and in animal models are welcome.

Potential topics include but are not limited to the following:

• Sedation
• Analgesia
• Subjective and objective monitoring of sedation and analgesia
• Critically ill children
• Postoperative sedoanalgesia
• Delirium
• Procedural analgesia
• Inhaled analgesia
• Non-pharmacological sedoanalgesia
• Withdrawal syndrome
• Efficiency of pharmacokinetics in children
• Toxicity of sedatives
• Neurodevelopment secondary effects of sedatives in children