BioMed Research International

Impact of Extracellular Matrix on Cellular Behavior: A Source of Molecular Targets in Disease


Publishing date
23 Oct 2015
Status
Published
Submission deadline
05 Jun 2015

1University of Patras, Patras, Greece

2Karolinska Institutet, Stockholm, Sweden

3University of Münster, Munster, Germany

4University of Insubria, Varese, Italy

5Medical University of South Carolina, Charleston, USA


Impact of Extracellular Matrix on Cellular Behavior: A Source of Molecular Targets in Disease

Description

Over the past decade, extracellular matrices (ECMs) have received significant attention due to their capability to form dynamic networks affecting cell functional properties and (patho) physiological processes. It is now well established that ECMs are not just space-filling materials that provide tissues and organs with mechanical strength, but they also interact with cells and generate signals through feedback loops to control cellular events.

Currently, there are strong indications that ECMs could potentially play a revolutionary role in drug discovery. The established key roles of specific ECM components in the development and progression of several diseases suggest that ECMs hold a great potential in driving the design and development of novel disease targeting tools.

This special issue will be focused on the role and impact of specific extracellular matrix effectors in cellular behavior as well as their potential targeting that could advance the treatment of various diseases, even those for which efficient therapies are not yet available.

To this aim, we invite investigators to contribute original research articles as well as review articles that will help in understanding the matrix pathobiology underlying specific pathologies and the development of matrix-based therapeutic strategies, and the current and expected challenges in this emerging research field that is expanding exponentially.

Potential topics include, but are not limited to:

  • Involvement of matrix effectors (proteoglycans, glycosaminoglycans, matrix-degrading enzymes, matricellular proteins, cytokines, collagenous proteins, matrix receptors, and integrins) in the interplays between mechanical and functional properties of ECM and disease (i.e., inflammation, cancer, and vascular/neural/muscular/skeletal diseases) progression and their potential for disease diagnosis and prognosis as well as for developing new tools for disease targeting
  • Recent advances and latest technologies to be applied in matrix-based management of disease (i.e., nanomedicine)
  • Role of extracellular matrix components in modulating normal cellular processes (i.e., autophagy, senescence, differentiation, and apoptosis) and abnormal ECM (collagen) accumulation in impaired wound healing that could reveal important therapeutic targets for controlling critical processes (i.e., EMT, angiogenesis, and fibrosis) in human pathologies
  • Lessons from matrix-mediated cellular functions in model organisms (i.e., Drosophila): strategies for developing novel pharmacological agents and tools for disease targeting
  • Bioinformatics approaches to characterize and target the regulatory networks formed by matrix effectors and their molecular partners in disease

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 482879
  • - Editorial

Impact of Extracellular Matrix on Cellular Behavior: A Source of Molecular Targets in Disease

Spyros S. Skandalis | Katalin Dobra | ... | Suniti Misra
  • Special Issue
  • - Volume 2015
  • - Article ID 198268
  • - Review Article

A Comprehensive Review on Cyclodextrin-Based Carriers for Delivery of Chemotherapeutic Cytotoxic Anticancer Drugs

Bina Gidwani | Amber Vyas
  • Special Issue
  • - Volume 2015
  • - Article ID 690721
  • - Research Article

Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines

Angeliki Korpetinou | Dionysios J. Papachristou | ... | Achilleas D. Theocharis
  • Special Issue
  • - Volume 2015
  • - Article ID 790203
  • - Review Article

Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?

Sami Albeiroti | Artin Soroosh | Carol A. de la Motte
  • Special Issue
  • - Volume 2015
  • - Article ID 427138
  • - Research Article

Organotypic Cultures of Intervertebral Disc Cells: Responses to Growth Factors and Signaling Pathways Involved

Harris Pratsinis | Dimitris Kletsas
  • Special Issue
  • - Volume 2015
  • - Article ID 861752
  • - Review Article

Mutations in Biosynthetic Enzymes for the Protein Linker Region of Chondroitin/Dermatan/Heparan Sulfate Cause Skeletal and Skin Dysplasias

Shuji Mizumoto | Shuhei Yamada | Kazuyuki Sugahara
  • Special Issue
  • - Volume 2015
  • - Article ID 453801
  • - Review Article

Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration

Mariana A. Soares | Felipe C. O. B. Teixeira | ... | Mariana P. Stelling
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision81 days
Acceptance to publication54 days
CiteScore2.410
Impact Factor2.197
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