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Inflammation in Muscle Repair, Aging, and Myopathies

Call for Papers

Numerous recent studies have expanded our knowledge on the complexity of the immune system and its contribution to skeletal muscle repair, aging, and myopathies. Indeed, it is becoming clear that a precisely regulated crosstalk between muscle and immune cells, involving paracrine/autocrine and cell-cell contact interactions, is required for successful repair and maintenance of muscle homeostasis. Alterations of these mechanisms lead to unsuccessful repair in response to acute injury, or following secondary damage as a consequence of aging or genetic neuromuscular defects. In fact, though the capacity of muscle to regenerate relies primarily on a specific population of muscle stem cells named satellite cells, the inflammatory cells that infiltrate the injured muscle appear to be as critical for successful regeneration. Conversely, if damage persists, as in chronic myopathies, inflammatory cell infiltration perpetuates and leads to progressive muscle fibrosis, thus exacerbating disease severity.

The main focus of this special issue will be to assemble studies that use different experimental approaches, by in vivo or in vitro models, to in-depth dissect the dynamic changes of specific immune cell populations, their crosstalk with other cell types within the muscle milieu, and their contribution to normal versus pathological muscle repair. Manuscripts reporting translation of basic immune cell biology to therapeutic approaches will also be welcomed, as well as reviews summarizing the most recent developments and ideas in the field. Potential topics include, but are not limited to:

  • Innate immune cells dynamics during physiological and pathological muscle repair
  • Interactions between innate immune cells and muscle stem cells in physiological and pathological muscle repair
  • Interactions between innate immune cells and nonmyogenic cells during muscle repair
  • Macrophage plasticity in skeletal muscle repair
  • Lymphocytes and other inflammatory cell types in normal versus pathological muscle repair
  • Inflammation and fibrosis in muscular dystrophies
  • Molecular regulation of skeletal muscle inflammation
  • Autoimmune inflammatory myopathies
  • Inflammation in aging muscle
  • Exercise and inflammation
  • Influence of immune responses in gene/stem cell therapies for muscle diseases
  • Inflammation-driven skeletal muscle wasting and cachexia
  • Emerging therapeutic options

Before submission, authors should carefully read over the journal’s Author Guidelines which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

Manuscript DueFriday, 14 February 2014
First Round of ReviewsFriday, 9 May 2014
Publication DateFriday, 27 June 2014

Lead Guest Editor

  • Marina Bouché, DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy

Guest Editors

  • Pura Muñoz-Cánoves, Pompeu Fabra University, 08003 Barcelona, Spain
  • Fabio Rossi, The Biomedical Research Centre, UBC, Vancouver, BC, Canada
  • Dario Coletti, Pierre et Marie Curie University, Paris 6 UR4, 75252 Paris Cedex 5, France