BioMed Research International

Bridging the Gap between Translational and Outcome Research in Cardiovascular Disease


Publishing date
07 Aug 2015
Status
Published
Submission deadline
20 Mar 2015

1Sapienza University, Rome, Italy

2Harefield Hospital, London, UK

3Virginia Commonwealth University, Richmond, USA

4Rutgers New Jersey Medical School, Newark, USA


Bridging the Gap between Translational and Outcome Research in Cardiovascular Disease

Description

Over the past few decades, the human life span has been extended and is expected to increase further in the next few years with a supplementary prolongation of life expectancy. Consequently, the prevalence of age-related conditions, such as cardiovascular disease (CVD), despite recent developments in cardiovascular research which have led to noteworthy steps in elucidating, preventing, and treating cardiovascular diseases, is continuously increasing, thus representing the leading cause for morbidity and mortality in high income countries.

Recent breakthroughs in stem cell biology, molecular genetic screening, proteomics, and metabolomics are changing the way investigators identify novel signal transduction pathways and functional cross-talks, making the development of new therapeutic strategies and protocols possible.

New insights into the mechanisms involved in cardiac myocyte turnover, hypertrophy, aging, and dysfunction have important therapeutic implications for an increasing population of patients with end-stage heart failure.

New technological tools are gaining more and more attractiveness due to their appraised clinical efficacy.

Improvements in the pharmacology field, thanks to the discovery of new molecules thumping selective targets, have led to a better-quality and personalized treatment of many cardiovascular diseases.

On the other hand, major efforts have been focused on bridging the gap between basic and translational research to clinical and outcome research, which aim to exploit the ever expanding set of information on prevalence, incidence, impact, and management of clinically relevant conditions in selected or real-world patients.

Given these premises, this special issue aims to integrate expertise from different disciplines toward the same objective inviting investigators to contribute original research articles and review articles able to stimulate the ongoing efforts to better understand the mechanism underlying cardiovascular disease as well as the development of therapeutic strategies to prevent or treat cardiovascular disease.

It is our hope that this special issue will serve as a resource for biomedical investigators at all levels, both those engaged in basic research and those involved in clinical practice in order to provide new insights into the way to future clinical translation.

This special issue of the journal will address some of these outstanding issues.

Potential topics include, but are not limited to:

  • Definition of pathophysiologic pathways and interplays involved in cardiovascular disease
  • Basic research
  • Stem cell therapy
  • Bioengineering approaches and bioartificial organs to assist regeneration in mammal tissues and organs
  • Translation from " bench to bedside"
  • Clinical research
  • Outcome research
  • Novel tools for the treatment of cardiovascular disease
  • Medical and ethical issues concerning cardiovascular disease and therapy

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 454680
  • - Editorial

Bridging the Gap between Translational and Outcome Research in Cardiovascular Disease

Giacomo Frati | Umberto Benedetto | ... | Sebastiano Sciarretta
  • Special Issue
  • - Volume 2015
  • - Article ID 483025
  • - Clinical Study

Recent Developments in Minimally Invasive Cardiac Surgery: Evolution or Revolution?

Antonino G. M. Marullo | Francesco G. Irace | ... | Ernesto Greco
  • Special Issue
  • - Volume 2015
  • - Article ID 861627
  • - Review Article

A Review of Computational Methods to Predict the Risk of Rupture of Abdominal Aortic Aneurysms

Tejas Canchi | S. D. Kumar | ... | Sriram Narayanan
  • Special Issue
  • - Volume 2015
  • - Article ID 293564
  • - Research Article

The Power of Phase I Studies to Detect Clinical Relevant QTc Prolongation: A Resampling Simulation Study

Georg Ferber | Ulrike Lorch | Jörg Täubel
  • Special Issue
  • - Volume 2015
  • - Article ID 864946
  • - Review Article

Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury

Tingyang Zhou | Chia-Chen Chuang | Li Zuo
  • Special Issue
  • - Volume 2015
  • - Article ID 151985
  • - Review Article

Evidential Value That Exercise Improves BMI -Score in Overweight and Obese Children and Adolescents

George A. Kelley | Kristi S. Kelley
  • Special Issue
  • - Volume 2015
  • - Article ID 835934
  • - Review Article

Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives

Carmela R. Balistreri | Silvio Buffa | ... | Giuseppe Mazzesi
  • Special Issue
  • - Volume 2015
  • - Article ID 542687
  • - Research Article

Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process

Valentina Cottignoli | Michela Relucenti | ... | Adriana Maras
  • Special Issue
  • - Volume 2015
  • - Article ID 841645
  • - Research Article

Space-Time Analysis to Identify Areas at Risk of Mortality from Cardiovascular Disease

Poliany C. O. Rodrigues | Emerson S. Santos | ... | Sandra S. Hacon
  • Special Issue
  • - Volume 2015
  • - Article ID 825397
  • - Research Article

Presence of Periodontopathic Bacteria DNA in Atheromatous Plaques from Coronary and Carotid Arteries

Malgorzata Szulc | Wojciech Kustrzycki | ... | Malgorzata Radwan-Oczko
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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