BioMed Research International

Atrial Fibrillation: Biophysics, Molecular Mechanisms, and Novel Therapies


Publishing date
15 May 2015
Status
Published
Submission deadline
26 Dec 2014

1National Heart and Lung Institute, London, UK

2Institute of Experimental Cardiology, Moscow, Russia

3Dr. Hari Singh Gour University, Sagar, India

4University of Parma and Humanitas Clinical and Research Center, Milan, Italy

5Washington University, Saint Louis, USA


Atrial Fibrillation: Biophysics, Molecular Mechanisms, and Novel Therapies

Description

Atrial fibrillation is the most common arrhythmia and is associated with increased morbidity and mortality. The incidences of atrial fibrillation are expected to continue to rise with the aging of the population. Research over the past decades has identified a multitude of pathophysiological processes contributing to the initiation, maintenance, and progression of atrial fibrillation. Ultimately, a comprehensive understanding of AF pathophysiology is needed to foster the development of improved diagnostic, pharmacological, and nonpharmacological therapeutic approaches and to greatly improve clinical management. This special issue aims to capture the most recent advances in the study of atrial fibrillation.

We invite investigators to contribute original research articles as well as review articles that will stimulate efforts to understand the molecular pathology underlying atrial arrhythmogenesis, development of novel strategies to treat these conditions, and the evaluation of outcomes. We are interested in articles that explore aspects of antiarrhythmic therapy in humans and also in animal models.

Potential topics include, but are not limited to:

  • Cellular electrophysiology and molecular mechanisms of atrial fibrillation initiation, progression, and maintenance
  • Role of autonomic nervous system in atrial fibrillation
  • Atrial fibrosis and fibrillation: basic and clinical investigation
  • Pacemaker abnormalities and atrial fibrillation
  • Computational modeling of basic mechanism of atrial fibrillation
  • Identifying risk factors for atrial fibrillation
  • Development and testing of novel antiarrhythmic drugs
  • Device-based therapies for atrial fibrillation treatment: now and in the future
  • Latest technologies for clinical evaluation and measuring outcomes
  • Alternative therapies for atrial fibrillation treatment
  • Prognostic impact of atrial fibrillation on clinical outcomes
  • Atrial fibrillation mapping and ablation

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 780671
  • - Editorial

Atrial Fibrillation: Biophysics, Molecular Mechanisms, and Novel Therapies

Alexey V. Glukhov | Leonid V. Rosenshtraukh | ... | Bas J. D. Boukens
  • Special Issue
  • - Volume 2015
  • - Article ID 424031
  • - Review Article

Novel Anticoagulants in Atrial Fibrillation: Monitoring, Reversal and Perioperative Management

Fadi Shamoun | Hiba Obeid | Harish Ramakrishna
  • Special Issue
  • - Volume 2015
  • - Article ID 798768
  • - Review Article

Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View

Michele Miragoli | Alexey V. Glukhov
  • Special Issue
  • - Volume 2015
  • - Article ID 798486
  • - Clinical Study

Impact of Dabigatran versus Phenprocoumon on ADP Induced Platelet Aggregation in Patients with Atrial Fibrillation with or without Concomitant Clopidogrel Therapy (the Dabi-ADP-1 and Dabi-ADP-2 Trials)

Amadea M. Martischnig | Julinda Mehilli | ... | Nikolaus Sarafoff
  • Special Issue
  • - Volume 2015
  • - Article ID 840356
  • - Clinical Study

Heartbeat Cycle Length Detection by a Ballistocardiographic Sensor in Atrial Fibrillation and Sinus Rhythm

Matthias Daniel Zink | Christoph Brüser | ... | Karl Mischke
  • Special Issue
  • - Volume 2015
  • - Article ID 496418
  • - Research Article

Chronotropic Modulation of the Source-Sink Relationship of Sinoatrial-Atrial Impulse Conduction and Its Significance to Initiation of AF: A One-Dimensional Model Study

Francesca Cacciani | Massimiliano Zaniboni
  • Special Issue
  • - Volume 2015
  • - Article ID 134756
  • - Research Article

Results from the Registry of Atrial Fibrillation (AFABE): Gap between Undiagnosed and Registered Atrial Fibrillation in Adults—Ineffectiveness of Oral Anticoagulation Treatment with VKA

Anna Panisello-Tafalla | Josep Lluís Clua-Espuny | ... | Miquel Gallofré López
  • Special Issue
  • - Volume 2015
  • - Article ID 402481
  • - Research Article

Atorvastatin Treatment for Atrial Fibrillation Reduces Serum High-Sensitivity C-Reactive Protein Levels

Fang-Cheng Su | Xi-Dong Li | ... | Hong-Yue Gu
  • Special Issue
  • - Volume 2015
  • - Article ID 910267
  • - Review Article

Diagnosing Paroxysmal Atrial Fibrillation: Are Biomarkers the Solution to This Elusive Arrhythmia?

P. J. Howlett | F. S. Hatch | ... | C. H. Fry
  • Special Issue
  • - Volume 2015
  • - Article ID 274817
  • - Clinical Study

Surgical Treatment of Concomitant Atrial Fibrillation: Focus onto Atrial Contractility

Claudia Loardi | Francesco Alamanni | ... | Mauro Pepi
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