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Behavioural Neurology
Volume 3, Issue 3, Pages 189-196
http://dx.doi.org/10.3233/BEN-1990-3305

Cortical Lewy Body Dementia

W. R. G. Gibb1,2

1University Department of Neurology, King’s College Hospital, Denmark Hill, London SE5, UK
2Department of Neurology, Institute of Psychiatry, De CrespigT!J Park, London SE58AF, UK

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In cortical Lewy body dementia the distribution of Lewy bodies in the nervous system follows that of Parkinson's disease, except for their greater profusion in the cerebral cortex. The cortical tangles and plaques of Alzheimer pathology are often present, the likely explanation being that Alzheimer pathology provokes dementia in many patients. Pure cortical Lewy body dementia without Alzheimer pathology is uncommon. The age of onset reflects that of Parkinson's disease, and clinical features, though not diagnostic, include aphasias, apraxias, agnosias, paranoid delusions and visual hallucinations. Parkinsonism may present before or after the dementia, and survival duration is approximately half that seen in Parkinson's disease without dementia.