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Behavioural Neurology
Volume 5, Issue 4, Pages 205-214
http://dx.doi.org/10.3233/BEN-1992-5402
Review

The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease

D. H. Jacobs and S. J. Huber

Department of Neurology, University of Kansas School of Medicine, Kansas City, Kansas, USA

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neuropsychologic data suggest an important role for the caudate nucleus (CN) in behavioral impairments in Huntington's disease (HD). These include abnormalities in executive function, egocentric visuospatial representations, communication, and retrieval of declarative memories, changes in personality, and psychiatric disturbances. Animal paradigms of CN lesions support a role for the CN in some of these behaviors. Current theories of basal ganglia function add explanatory value to the role of the CN in these behaviors. A disconnection of the caudate from limbic structures, including the amygdala may account for many nonmotor behaviors observed in HD.