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Behavioural Neurology
Volume 8, Issue 1, Pages 43-46
Case Report

Psychiatric Symptomatology in Early-Onset Binswanger’s Disease: Two Case Reports

R. M. Lawrence1 and J. C. Hillam2

1Department of Psychogeriatric Medicine and Neuropsychiatry, Purley Hospital, 50 Pampisford Rd, Purley, Surrey CR8 2NE, UK
2Department of Psychiatry, Whittington Hospital, Highgate Hill, London N19 5NF, UK

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We describe two cases of Binswanger's disease of pre-senile onset which presented with affective and psychotic symptoms well before the appearance of cognitive deterioration and neurological signs, initially evading an accurate diagnosis. Psychiatrists should be aware of white matter disease and its role in the pathogenesis of psychiatric illness. Particular attention should be given to a history of hypertension as a risk factor in the early identification of these cases.