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Behavioural Neurology
Volume 10, Issue 4, Pages 121-127
http://dx.doi.org/10.3233/BEN-1997-10404

SPECT Findings in Alzheimer’s Disease and Parkinson’s Disease with Dementia

S. E. Starkstein,1,2 S. Vázquez,3 G. Petracca,1 L. Sabe,1 M. Merello,2 and R. Leiguarda2

1Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina
2Department of Clinical Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina
3Department of Nuclear Medicine, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina

Received 11 July 1996; Accepted 12 November 1996

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We examined, with single photon emission tomography (SPECT) and (99mTc)-HMPAO, 18 patients with idiopathic Parkinson's disease and no dementia (PD), 12 patients with PD and dementia, 24 patients with probable Alzheimer's disease (AD), and 14 controls. While the three patient groups showed significantly lower perfusion in frontal inferior and temporal inferior areas as compared to controls, both demented groups showed significantly more severe bilateral hypoperfusion in superior frontal, superior temporal and parietal areas as compared to non-demented PD patients and controls. On the other hand, no significant differences in cerebral perfusion were found between patients with AD and patients with PD and dementia. In conclusion, our findings demonstrated specific but similar cerebral perfusion deficits in demented patients with either AD or PD.