Behavioural Neurology

Behavioural Neurology / 2003 / Article

Open Access

Volume 14 |Article ID 843760 |

Claus G. Haase, Michael Tinnefeld, Marc Lienemann, Reinhard E. Ganz, Pedro M. Faustmann, "Depression and Cognitive Impairment in Disability-Free Early Multiple Sclerosis", Behavioural Neurology, vol. 14, Article ID 843760, 7 pages, 2003.

Depression and Cognitive Impairment in Disability-Free Early Multiple Sclerosis

Received21 Apr 2003
Accepted21 Apr 2003


Cognitive and emotional capabilities were evaluated in 73 female patients with stable relapsing-remitting definite, and/or laboratory-supported multiple sclerosis (MS) and were compared with 32 matched healthy controls. Patients were categorized according to their score in the expanded disability status scale (EDSS) to either no (EDSS 0, n = 33) or few clinical signs (EDSS 1–2, n = 40) of MS without physical disability. Patients with EDSS > 0 were characterized by significantly (p These results indicate that depression may present as an early sign in MS followed by cognitive impairment, in particular visuo-spatial short-term memory, before physical disability appears. Neuropsychological tests as mentioned here could serve as early diagnostic tools to detect subtle disease progression and to initiate and monitor disease modifying therapies.Patients with EDSS > 0 were characterized by significantly (p < 0.001) higher scores on “von Zerssen’s“ depression scale, compared to controls. Patients with higher EDSS scores (1–2) showed significantly decreased performance with respect to the total score of Kimura’s Recurring-Figures-Test (p < 0.001), in addition. Regarding visuo-constructive functioning, patients with EDSS = 0 performed to a significantly lower level (p < 0.001), compared to controls.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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