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Behavioural Neurology
Volume 18, Issue 3, Pages 159-164

The Clinical Overlap between the Corticobasal Degeneration Syndrome and Other Diseases of the Frontotemporal Spectrum: Three Case Reports

Alberto Raggi,1,2 Alessandra Marcone,1 Sandro Iannaccone,1 Valeria Ginex,1,2 Daniela Perani,2,3 and Stefano F. Cappa1,2

1Department of Neurology and Neurorehabilitation, San Raffaele Turro Hospital, Milan, Italy
2Department of Psychology and Neuroscience, Vita-Salute San Raffaele University, Milan, Italy
3Department of Nuclear Medicine, San Raffaele Scientific Institute and Milano Bicocca University, Milan, Italy

Received 14 August 2007; Accepted 14 August 2007

Copyright © 2007 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The corticobasal degeneration syndrome has been suggested to be part of a complex of conditions (including the different subtypes of frontotemporal dementia and progressive supranuclear palsy), which reflect a spectrum of pathological substrates. This concept is supported by the frequent clinical overlap that can be observed among patients diagnosed with these conditions. We report three clinical cases, characterized by the overlap of the clinical features of corticobasal degeneration syndrome with, respectively, nonfluent progressive aphasia, progressive supranuclear palsy and semantic dementia. Current diagnostic criteria emphasize differences in clinical presentation, which probably reflect the preferential location of pathology in the early stages of disease. However, with disease progression, a considerable clinical overlap can be expected among the different syndromes. This concept should be extended not only to the cognitive and behavioural features of the frontotemporal dementia subtypes, but also to the movement disorders of corticobasal degeneration and supranuclear palsy.