Behavioural Neurology

Behavioural Neurology / 2009 / Article
Special Issue

Alzheimer’s Disease and Mild Cognitive Impairment: New Insights from Imaging

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Volume 21 |Article ID 246892 |

Adam M. Brickman, Scott A. Small, Adam Fleisher, "Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI", Behavioural Neurology, vol. 21, Article ID 246892, 8 pages, 2009.

Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI

Received16 Oct 2009
Accepted16 Oct 2009


During its earliest stage, before cell loss and independent of amyloid plaques and neurofibrillary tangles, Alzheimer's disease (AD) causes synaptic loss affecting the basal functional properties of neurons. In principle, synaptic loss can be detected by measuring AD-induced changes in basal function, or by measuring stimulus-evoked responses on top of basal changes. Functional magnetic resonance imaging (fMRI) is sensitive to both basal changes and evoked-responses, and there are therefore two experimental approaches in which fMRI can be used to pinpoint synaptic loss in AD. In this review, we will compare and contrast both approaches for pinpointing when and where synaptic loss in AD begins and for monitoring therapeutic efficacy.

Copyright © 2009 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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