Behavioural Neurology

Behavioural Neurology / 2009 / Article

Open Access

Volume 21 |Article ID 791491 |

Yumiko Kito, Hiroaki Kazui, Yoshihiko Kubo, Tetsuhiko Yoshida, Masahiko Takaya, Tamiki Wada, Keiko Nomura, Mamoru Hashimoto, Shingo Ohkawa, Hiroji Miyake, Masatsune Ishikawa, Masatoshi Takeda, "Neuropsychiatric Symptoms in Patients with Idiopathic Normal Pressure Hydrocephalus", Behavioural Neurology, vol. 21, Article ID 791491, 10 pages, 2009.

Neuropsychiatric Symptoms in Patients with Idiopathic Normal Pressure Hydrocephalus

Received27 Nov 2009
Accepted27 Nov 2009


Objective: To clarify the characteristics of neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus (iNPH).Methods: Neuropsychiatric symptoms of 64 iNPH patients with mild triad symptoms from three kinds of hospitals were evaluated with the Neuropsychiatric Inventory (NPI) and compared with 126 patients with Alzheimer’s disease (AD).Results: The most frequently observed neuropsychiatric symptom in the iNPH patients was apathy followed by anxiety and aggression. No symptom was more prevalent or more severe in iNPH than in AD. The severity of cognitive impairment was correlated with both aberrant motor activity and apathy.Conclusions: Neuropsychiatric symptoms were mild in patients with iNPH and apathy was the most prevalent symptom. The correlation between neuropsychiatric symptoms and cognitive impairment in iNPH appears to arise from a common pathology in the frontal lobe.

Copyright © 2009 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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