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Behavioural Neurology
Volume 24, Issue 1, Pages 27-34

Peri-Ictal and Ictal Cognitive Dysfunction in Epilepsy

Lavanya Vijayaraghavan, Subbulakshmy Natarajan, and Ennapadam Srinivas Krishnamoorthy

The Institute of Neurological Sciences, Voluntary Health Services Medical Centre, Rajiv Gandhi Salai, Taramani, Chennai, Tamil Nadu, India

Received 23 March 2011; Accepted 23 March 2011

Copyright © 2011 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Disturbances in cognitive function, particularly memory, are a common complaint of patients with epilepsy. Factors contributing to cognitive dysfunction are the type of epilepsy, type and frequency of seizures, anti-epileptic drugs and the location of underlying brain lesions. Whilst a great deal of attention has been paid to permanent cognitive impairment, the nature and underlying mechanisms of ictal and peri-ictal cognitive changes are poorly understood. In-depth investigation of seizure related cognitive dysfunction is of great clinical relevance, as these changes are potentially reversible and treatable, thus reducing the cumulative effect of frequent seizures Greater knowledge of peri-ictal and ictal cognitive dysfunction would improve seizure prediction, localization of seizure focus and assessment of treatment effectiveness, greatly reducing distress and disability. This paper will review current understanding of peri-ictal and ictal cognitive dysfunction and discuss future directions for research.