Behavioural Neurology

Behavioural Neurology / 2012 / Article

Open Access

Volume 25 |Article ID 673610 |

Ignacio Obeso, Enrique Casabona, Maria Luisa Bringas, Lázaro Álvarez, Marjan Jahanshahi, "Semantic and Phonemic Verbal Fluency in Parkinson’s Disease: Influence of Clinical and Demographic Variables", Behavioural Neurology, vol. 25, Article ID 673610, 8 pages, 2012.

Semantic and Phonemic Verbal Fluency in Parkinson’s Disease: Influence of Clinical and Demographic Variables

Received19 Jan 2012
Accepted19 Jan 2012


Changes of cognitive function in PD have been extensively documented and defined as a ‘frontal’ type executive dysfunction. One of the main components of this executive dysfunction is the impairment of verbal fluency. The aim of the present study was to assess semantic and phonemic fluency in a large sample of PD patients and to investigate the effect of clinical and sociodemographic variables on verbal fluency in this patient group.Three hundred patients with idiopathic Parkinson's disease who were consecutive referrals to our clinic and 50 age and education matched healthy controls completed the phonemic and semantic verbal fluency tasks. Both phonemic and semantic verbal fluency were significantly impaired in PD patients relative to matched controls. Stage of illness, presence of depression, education and age influenced verbal fluency measures. Regression analyses established that global measures of cognitive ability (MMSE) and executive function (FAB) and side of onset of motor symptoms predicted 36–37% of variance of phonemic or semantic verbal fluency measures. Thus, future studies aimed at assessing cognitive functioning in PD patients treated by deep brain stimulation (DBS) should adequately take into account several factors (stage of illness, depression, executive functioning) which may potentially influence performance on verbal fluency tasks.

Copyright © 2012 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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