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Behavioural Neurology
Volume 25, Issue 1, Pages 3-11

Auditory Delta Event-Related Oscillatory Responses are Decreased in Alzheimer’s Disease

G. G. Yener,1,2,3 B. Güntekin,3 D. Necioglu Örken,4 E. Tülay,3 H. Forta,4 and E. Başar3

1Departments of Neurology and Neurosciences; Dokuz Eylül University, Izmir, Turkey
2Brain Dynamics and Multidisciplinary Research Center, Dokuz Eylül University, Izmir, Turkey
3Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul, Turkey
4Sisli Etfal State Hospital, Department of Neurology, Istanbul, Turkey

Received 26 December 2011; Accepted 26 December 2011

Copyright © 2012 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: Visual delta event-related (ERO) and evoked oscillations (EO) of Alzheimer patients (AD) are different than healthy. In the present study, the analysis is extented to include auditory ERO and EO in AD. The rationale is to reveal whether the auditory ERO delta responses are also reduced, and whether this is a general phenomenon in Alzheimer patients upon applying stimuli with cognitive load.

Methods: Thirty-four mild AD subjects (17 de-novo and 17 medicated (cholinergic)) and seventeen healthy controls were included. Auditory oddball paradigm and sensory auditory stimuli were applied to the subjects. Oscillatory responses were analyzed by measuring maximum amplitudes in delta frequency range (0.5–3.5 Hz).

Results: Auditory delta ERO (0.5–3.5 Hz) responses of healthy controls were higher than either de-novo AD or medicated AD group, without a difference between two AD subgroups. Furthermore, the auditory EO after presentation of tone bursts yielded no group difference.

Conclusion: Our findings imply that delta ERO is highly unstable in AD patients in comparison to age-matched healthy controls only during the cognitive paradigm. Our results favor the hypothesis that neural delta networks are activated during cognitive tasks and that the reduced delta response is a general phenomenon in AD, due to cognitive impairment.