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Behavioural Neurology
Volume 2014, Article ID 294149, 6 pages
Research Article

Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats

1Department of Biology, Faculty of Biological Science, North Tehran Branch, Islamic Azad University, Tehran 19395-6558, Iran
2Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran 19395-6558, Iran
3Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 19395-6558, Iran
4Department of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran 19395-6558, Iran

Received 9 February 2014; Revised 29 June 2014; Accepted 22 July 2014; Published 7 August 2014

Academic Editor: Antonio Pisani

Copyright © 2014 Zohreh Sadat Nasihatkon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Stress and its consequences are among the causes of accidents. Objective. The effects of intraventral tegmental area (I-VTA) memantine on the plasma corticosterone and eating parameters disturbance induced by acute stress were investigated. Methods. Male Wistar rats (W: 250–300 g) were divided into control and experiential groups, each of which received memantine either intra-VTA or peripherally. One week after bilateral cannulation, the rats received memantine (1 and 5 μg/Rat) five min before electroshock stress. The other experimental groups received memantine (1 and 5 mg/kg) intraperitoneally 30 min before stress. The control groups received saline or memantine but did not experience stress. Food and water intake and plasma corticosterone level were recorded. Results. Results showed that stress decreases food intake but does not change water intake and increase in plasma corticosterone level. Intraperitoneal memantine administration slightly inhibits the stress effects on food intake. However, water intake and plasma corticosterone level were increased. Intra-VTA memantine reduces the effects of stress on corticosterone and water intake. Conclusion. It could be concluded that inhibition of glutamate NMDA receptors in the VTA by memantine leads to the inhibition of the eating behavior parameters and plasma corticosterone level disturbance induced by stress in rats.