Research Article

Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells

Table 4

Percentage of apoptotic cells in differentiated SH-SY5Y cells after treatment.

TreatmentApoptotic cells (% of total)

Control8.00 ± 2.31
Glutamate (20 mM)27.33 ± 2.91**
Glutamate + insulin (0.1 μM )13.00 ± 2.00#
Glutamate + insulin (1 μM)11.67 ± 2.90#

Values are expressed as mean ± SEM of three tests in triplicate. Statistical analysis was done by using one-way ANOVA followed by Tukey’s multiple comparison test. **P < 0.01 compared to control group. #P < 0.05 compared to glutamate group.