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Behavioural Neurology
Volume 2014, Article ID 815215, 11 pages
http://dx.doi.org/10.1155/2014/815215
Review Article

rTMS in the Treatment of Drug Addiction: An Update about Human Studies

1Addiction Department, ULSS 20, Via Germania 20, 37136 Verona, Italy
2Department of Neurological and Movement Sciences, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy
3Friends Research Institute, Inc., 1040 Park Avenue, Suite 103, Baltimore, MD 21201, USA
4National Coordination Centre for NIDA Collaborations, Via Germania 20, 37136 Verona, Italy
5Department for Anti-Drug Policies of the Presidency of Ministers’ Council of Italy, Via dei Laterani 34, 00184 Roma, Italy

Received 16 January 2013; Accepted 22 April 2013; Published 23 January 2014

Academic Editor: Stefano F. Cappa

Copyright © 2014 Elisa Bellamoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Z. Goldstein and N. D. Volkow, “Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex,” The American Journal of Psychiatry, vol. 159, no. 10, pp. 1642–1652, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. American Psychiatric Association (APA), Diagnostic and Statistical Manual of Mental Disorders, Text Revision (DSM-IV-TR), American Psychiatric Association, Washington, DC, USA, 4th edition, 2000.
  3. S. E. Hyman and R. C. Malenka, “Addiction and the brain: the neurobiology of compulsion and its persistence,” Nature Reviews Neuroscience, vol. 2, no. 10, pp. 695–703, 2001. View at Google Scholar
  4. C. P. O’Brien, “Evidence-based treatments of addiction,” Philosophical Transactions of the Royal Society B, vol. 363, no. 1507, pp. 3277–3286, 2008. View at Publisher · View at Google Scholar
  5. J. Feil and A. Zangen, “Brain stimulation in the study and treatment of addiction,” Neuroscience and Biobehavioral Reviews, vol. 34, no. 4, pp. 559–574, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Brainin, M. Barnes, J.-C. Baron et al., “Guidance for the preparation of neurological management guidelines by EFNS scientific task forces—revised recommendations 2004,” European Journal of Neurology, vol. 11, no. 9, pp. 577–581, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Wagner, A. Valero-Cabre, and A. Pascual-Leone, “Noninvasive human brain stimulation,” Annual Review of Biomedical Engineering, vol. 9, no. 1, pp. 527–565, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Hallett, “Transcranial magnetic stimulation: a primer,” Neuron, vol. 55, no. 2, pp. 187–199, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Rachid and G. Bertschy, “Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of depression: a critical appraisal of the last 10 years,” Clinical Neurophysiology, vol. 36, no. 3, pp. 157–183, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. Z. Daskalakis, B. Christensen, P. Fitzgerald, and R. Chen, “Transcranial magnetic stimulation: a new investigational and treatment tool in psychiatry,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 14, no. 4, pp. 406–415, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Hallett, “Transcranial magnetic stimulation: a primer,” Neuron, vol. 55, no. 2, pp. 187–199, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. U. Ziemann, “TMS induced plasticity in human cortex,” Reviews in the Neurosciences, vol. 15, no. 4, pp. 253–266, 2004. View at Google Scholar · View at Scopus
  13. E. M. Wassermann, “Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation,” Electroencephalography and Clinical Neurophysiology, vol. 108, no. 1, pp. 1–16, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Machii, D. Cohen, C. Ramos-Estebanez, and A. Pascual-Leone, “Safety of rTMS to non-motor cortical areas in healthy participants and patients,” Clinical Neurophysiology, vol. 117, no. 2, pp. 455–471, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Levkovitz, Y. Roth, E. V. Harel, Y. Braw, A. Sheer, and A. Zangen, “A randomized controlled feasibility and safety study of deep transcranial magnetic stimulation,” Clinical Neurophysiology, vol. 118, no. 12, pp. 2730–2744, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Rossi, M. Hallett, P. M. Rossini, and A. Pascual-Leone, “Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research,” Clinical Neurophysiology, vol. 120, no. 12, pp. 2008–2039, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. C. K. Loo, T. F. McFarquhar, and P. B. Mitchell, “A review of the safety of repetitive transcranial magnetic stimulation as a clinical treatment for depression,” International Journal of Neuropsychopharmacology, vol. 11, no. 1, pp. 131–147, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. U. Ziemann, S. Lonnecker, and W. Paulus, “Inhibition of human motor cortex by ethanol,” Brain, vol. 118, no. 6, pp. 1437–1446, 1995. View at Google Scholar · View at Scopus
  19. S. Kähkönen, M. Kesäniemi, V. V. Nikouline et al., “Ethanol modulates cortical activity: direct evidence with combined TMS and EEG,” NeuroImage, vol. 14, no. 2, pp. 322–328, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Kähkönen, J. Wilenius, V. V. Nikulin, M. Ollikainen, and R. J. Ilmoniemi, “Alcohol reduces prefrontal cortical excitability in humans: a combined TMS and EEG study,” Neuropsychopharmacology, vol. 28, no. 4, pp. 747–754, 2003. View at Google Scholar · View at Scopus
  21. A. Conte, M. L. Attilia, F. Gilio et al., “Acute and chronic effects of ethanol on cortical excitability,” Clinical Neurophysiology, vol. 119, no. 3, pp. 667–674, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Nardone, J. Bergmann, M. Kronbichler et al., “Altered motor cortex excitability to magnetic stimulation in alcohol withdrawal syndrome,” Alcoholism, vol. 34, no. 4, pp. 628–632, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Lang, A. Hasan, E. Sueske, W. Paulus, and M. A. Nitsche, “Cortical hypoexcitability in chronic smokers? A transcranial magnetic stimulation study,” Neuropsychopharmacology, vol. 33, no. 10, pp. 2517–2523, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. P. B. Fitzgerald, S. Williams, and Z. J. Daskalakis, “A transcranial magnetic stimulation study of the effects of cannabis use on motor cortical inhibition and excitability,” Neuropsychopharmacology, vol. 34, no. 11, pp. 2368–2375, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Oliveri and G. Calvo, “Increased visual cortical excitability in ecstasy users: a transcranial magnetic stimulation study,” Journal of Neurology Neurosurgery and Psychiatry, vol. 74, no. 8, pp. 1136–1138, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. N. N. Boutros, S. H. Lisanby, H. Tokuno et al., “Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation,” Biological Psychiatry, vol. 49, no. 4, pp. 369–373, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. N. N. Boutros, S. H. Lisanby, D. McClain-Furmanski, G. Oliwa, D. Gooding, and T. R. Kosten, “Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings,” Journal of Psychiatric Research, vol. 39, no. 3, pp. 295–302, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Sundaresan, U. Ziemann, J. Stanley, and N. Boutros, “Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study,” NeuroReport, vol. 18, no. 3, pp. 289–292, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. P. M. Rossini and S. Rossi, “Transcranial magnetic stimulation: diagnostic, therapeutic, and research potential,” Neurology, vol. 68, no. 7, pp. 484–488, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. Z. J. Daskalakis, B. Möller, B. K. Christensen, P. B. Fitzgerald, C. Gunraj, and R. Chen, “The effects of repetitive transcranial magnetic stimulation on cortical inhibition in healthy human subjects,” Experimental Brain Research, vol. 174, no. 3, pp. 403–412, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. P. B. Fitzgerald, S. Fountain, and Z. J. Daskalakis, “A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition,” Clinical Neurophysiology, vol. 117, no. 12, pp. 2584–2596, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Kanno, M. Matsumoto, H. Togashi, M. Yoshioka, and Y. Mano, “Effects of acute repetitive transcranial magnetic stimulation on dopamine release in the rat dorsolateral striatum,” Journal of the Neurological Sciences, vol. 217, no. 1, pp. 73–81, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. M. E. Keck, T. Welt, M. B. Müller et al., “Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system,” Neuropharmacology, vol. 43, no. 1, pp. 101–109, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. A. P. Strafella, T. Paus, J. Barrett, and A. Dagher, “Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus,” The Journal of Neuroscience, vol. 21, no. 15, p. RC157, 2001. View at Google Scholar · View at Scopus
  35. S. S. Cho and A. P. Strafella, “rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex,” PLoS ONE, vol. 4, no. 8, Article ID e6725, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. P. B. Fitzgerald, A. Sritharan, Z. J. Daskalakis, A. R. de Castella, J. Kulkarni, and G. Egan, “A functional magnetic resonance imaging study of the effects of low frequency right prefrontal transcranial magnetic stimulation in depression,” Journal of Clinical Psychopharmacology, vol. 27, no. 5, pp. 488–492, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Bortolomasi, A. Minelli, G. Fuggetta et al., “Long-lasting effects of high frequency repetitive transcranial magnetic stimulation in major depressed patients,” Psychiatry Research, vol. 150, no. 2, pp. 181–186, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Kito, K. Fujita, and Y. Koga, “Regional cerebral blood flow changes after low-frequency transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in treatment-resistant depression,” Neuropsychobiology, vol. 58, no. 1, pp. 29–36, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. S. H. Lisanby, M. M. Husain, P. B. Rosenquist et al., “Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial,” Neuropsychopharmacology, vol. 34, no. 2, pp. 522–534, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. B. D. Greenberg, U. Ziemann, G. Corá-Locatelli et al., “Altered cortical excitability in obsessive-compulsive disorder,” Neurology, vol. 54, no. 1, pp. 142–147, 2000. View at Google Scholar · View at Scopus
  41. P. Alonso, J. Pujol, N. Cardoner et al., “Right prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a double-blind, placebo-controlled study,” The American Journal of Psychiatry, vol. 158, no. 7, pp. 1143–1145, 2001. View at Google Scholar
  42. S.-H. Lee, W. Kim, Y.-C. Chung et al., “A double blind study showing that two weeks of daily repetitive TMS over the left or right temporoparietal cortex reduces symptoms in patients with schizophrenia who are having treatment-refractory auditory hallucinations,” Neuroscience Letters, vol. 376, no. 3, pp. 177–181, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. Jin, S. G. Potkin, A. S. Kemp et al., “Therapeutic effects of individualized alpha frequency transcranial magnetic stimulation (αTMS) on the negative symptoms of schizophrenia,” Schizophrenia Bulletin, vol. 32, no. 3, pp. 556–561, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. N. Goyal, S. H. Nizamie, and P. Desarkar, “Efficacy of adjuvant high frequency repetitive transcranial magnetic stimulation on negative and positive symptoms of schizophrenia: preliminary results of a double-blind sham-controlled study,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 19, no. 4, pp. 464–467, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Stanford, Z. Sharif, C. Corcoran, N. Urban, D. Malaspina, and S. H. Lisanby, “rTMS strategies for the study and treatment of schizophrenia: a review,” International Journal of Neuropsychopharmacology, vol. 11, no. 4, pp. 563–576, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Johann, R. Wiegand, A. Kharraz et al., “Repetitiv transcranial magnetic stimulation in nicotine dependence,” Psychiatrische Praxis, vol. 30, supplement 2, pp. S129–S131, 2003. View at Google Scholar · View at Scopus
  47. P. Eichhammer, M. Johann, A. Kharraz et al., “High-frequency repetitive transcranial magnetic stimulation decreases cigarette smoking,” Journal of Clinical Psychiatry, vol. 64, no. 8, pp. 951–953, 2003. View at Google Scholar · View at Scopus
  48. R. Amiaz, D. Levy, D. Vainiger, L. Grunhaus, and A. Zangen, “Repeated high-frequency transcranial magnetic stimulation over the dorsolateral prefrontal cortex reduces cigarette craving and consumption,” Addiction, vol. 104, no. 4, pp. 653–660, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. V. C. Wing, I. Bacher, B. S. Wu, Z. J. Daskalakis, and T. P. George, “High frequency repetitive transcranial magnetic stimulation reduces tobacco craving in schizophrenia,” Schizophrenia Research, vol. 139, no. 1, pp. 266–266, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. J. E. Rose, F. J. McClernon, B. Froeliger, F. M. Behm, X. Preud'Homme, and A. D. Krystal, “Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes,” Biological Psychiatry, vol. 70, no. 8, pp. 794–799, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. B. R. Mishra, S. H. Nizamie, B. Das, and S. K. Praharaj, “Efficacy of repetitive transcranial magnetic stimulation in alcohol dependence: a sham-controlled study,” Addiction, vol. 105, no. 1, pp. 49–55, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. S. C. Herremans, C. Baeken, N. Vanderbruggen et al., “No influence of one right-sided prefrontal HF-rTMS session on alcohol craving in recently detoxified alcohol-dependent patients: results of a naturalistic study,” Drug and Alcohol Dependence, vol. 120, no. 1–3, pp. 209–213, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. J. Höppner, T. Broese, L. Wendler, C. Berger, and J. Thome, “Repetitive transcranial magnetic stimulation (rTMS) for treatment of alcohol dependence,” World Journal of Biological Psychiatry, vol. 12, no. 1, pp. 57–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. D. de Ridder, S. Vanneste, S. Kovacs, S. Sunaert, and G. Dom, “Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: an fMRI and LORETA EEG study,” Neuroscience Letters, vol. 496, no. 1, pp. 5–10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  55. J. A. Camprodon, J. Martínez-Raga, M. Alonso-Alonso, M.-C. Shih, and A. Pascual-Leone, “One session of high frequency repetitive transcranial magnetic stimulation (rTMS) to the right prefrontal cortex transiently reduces cocaine craving,” Drug and Alcohol Dependence, vol. 86, no. 1, pp. 91–94, 2007. View at Publisher · View at Google Scholar · View at Scopus
  56. E. Politi, E. Fauci, A. Santoro, and E. Smeraldi, “Daily sessions of transcranial magnetic stimulation to the left prefrontal cortex gradually reduce cocaine craving,” The American Journal on Addictions, vol. 17, no. 4, pp. 345–346, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. S. E. Hyman, R. C. Malenka, and E. J. Nestler, “Neural mechanisms of addiction: the role of reward-related learning and memory,” Annual Review of Neuroscience, vol. 29, no. 1, pp. 565–598, 2006. View at Publisher · View at Google Scholar · View at Scopus
  58. L. J. M. J. Vanderschuren and P. W. Kalivas, “Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies,” Psychopharmacology, vol. 151, no. 2-3, pp. 99–120, 2000. View at Google Scholar · View at Scopus
  59. M. E. Wolf, X. Sun, S. Mangiavacchi, and S. Z. Chao, “Psychomotor stimulants and neuronal plasticity,” Neuropharmacology, vol. 47, supplement 1, pp. 61–79, 2004. View at Publisher · View at Google Scholar · View at Scopus
  60. P. W. Kalivas and C. O'Brien, “Drug addiction as a pathology of staged neuroplasticity,” Neuropsychopharmacology, vol. 33, no. 1, pp. 166–180, 2008. View at Publisher · View at Google Scholar · View at Scopus
  61. J. A. Kauer and R. C. Malenka, “Synaptic plasticity and addiction,” Nature Reviews Neuroscience, vol. 8, no. 11, pp. 844–858, 2007. View at Publisher · View at Google Scholar · View at Scopus
  62. B. J. Everitt, D. Belin, D. Economidou, Y. Pelloux, J. W. Dalley, and T. W. Robbins, “Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction,” Philosophical Transactions of the Royal Society B, vol. 363, no. 1507, pp. 3125–3135, 2008. View at Publisher · View at Google Scholar · View at Scopus
  63. A. E. Rorie and W. T. Newsome, “A general mechanism for decision-making in the human brain?” Trends in Cognitive Sciences, vol. 9, no. 2, pp. 41–43, 2005. View at Publisher · View at Google Scholar · View at Scopus
  64. S. H. Mitchell, “Measuring impulsivity and modeling its association with cigarette smoking,” Behavioral and cognitive Neuroscience Reviews, vol. 3, no. 4, pp. 261–275, 2004. View at Google Scholar · View at Scopus
  65. D. Knoch, L. R. R. Gianotti, A. Pascual-Leone et al., “Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior,” Journal of Neuroscience, vol. 26, no. 24, pp. 6469–6472, 2006. View at Publisher · View at Google Scholar · View at Scopus
  66. V. C. Wing, M. S. Barr, C. E. Wass et al., “Brain stimulation methods to treat tobacco addiction,” Brain Stimulation, vol. 6, no. 3, pp. 221–230, 2012. View at Google Scholar
  67. M. S. Barr, P. B. Fitzgerald, F. Farzan, T. P. George, and Z. J. Daskalakis, “Transcranial magnetic stimulation to understand the pathophysiology and treatment of substance use disorders,” Current Drug Abuse Reviews, vol. 1, no. 3, pp. 328–339, 2008. View at Google Scholar · View at Scopus
  68. R. Nardone, J. Bergmann, P. Lochner et al., “Non-invasive brain stimulation in the functional evaluation of alcohol effects and in the treatment of alcohol craving: a review,” Neuroscience Research, vol. 74, no. 3-4, pp. 169–176, 2012. View at Google Scholar
  69. S. C. Herremans and C. Baeken, “The current perspective of neuromodulation techniques in the treatment of alcohol addiction: a systematic review,” Psychiatria Danubina, vol. 24, supplement 1, pp. S14–S20, 2012. View at Google Scholar
  70. P. B. Fitzgerald and Z. J. Daskalakis, “A practical guide to the use of repetitive transcranial magnetic stimulation in the treatment of depression,” Brain Stimulation, vol. 5, no. 3, pp. 287–296, 2012. View at Publisher · View at Google Scholar · View at Scopus
  71. A. A. Gershon, P. N. Dannon, and L. Grunhaus, “Transcranial magnetic stimulation in the treatment of depression,” The American Journal of Psychiatry, vol. 160, no. 5, pp. 835–845, 2003. View at Publisher · View at Google Scholar · View at Scopus
  72. M. S. Barr, F. Farzan, V. C. Wing, T. P. George, P. B. Fitzgerald, and Z. J. Daskalakis, “Repetitive transcranial magnetic stimulation and drug addiction,” International Review of Psychiatry, vol. 23, no. 5, pp. 454–466, 2011. View at Publisher · View at Google Scholar · View at Scopus