Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat

<div>Home cage activity (HCA). Changes in the locomotor activity, reflecting explorative and searching behavior, were assessed in the animals’ home cage prior to MFB-HFS and during the first 4 days of stimulation (a). During the early period of MFB-HFS, on average, most animals tended to increase their locomotor activity for at least 72 hours, some for longer periods. At the end of the stimulation period changes in locomotor activity coinciding with the turning-off of the stimulation were measured by using the final day of stimulation as the baseline and comparing it to locomotor activity over the first 4 days without stimulation (b). On average, switching off the MFB-HFS induced a reduction in HCA. See text for more detail.</div>

Behavioural Neurology

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Figure 5

Figure 5: Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat 

Figure 5 | Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat 