Research Article

Long-Term Neuropsychological Sequelae in HIV-Seronegative Cryptococcal Meningoencephalitis Patients with and without Ventriculoperitoneal Shunts: A Cine MRI Study

Table 1

Demographic data of cryptococcal meningitis patients and controls.

DemographicsPatients with shuntsPatients without shuntsNormal or

Gender (male/female)9/17/128/40.0220.978
Age at follow-up53.70 ± 14.3054.00 ± 9.8751.47 ± 13.300.1900.827
Education9.30 ± 5.4610.63 ± 4.6312.56 ± 4.222.1840.124
Duration of follow-up (months)a73.5 (21.25, 113.25)116 (38.5, 130.75)−1.2890.197
Hospitalization duration (days)a53 (33.5, 60.5)25 (17, 43)−2.3980.016
Glasgow Coma Scale at admissiona15 (13.75, 15)15 (14, 15)−0.3040.761
Glasgow Coma Scale at dischargea15 (13.75, 15)15 (15, 15)−0.8530.394
CSF Cryptococcal Ag titer at admissiona1024 (320, 1536)384 (96.5, 2816)−0.8420.400
Max CSF Cryptococcal Ag titer during hospitalizationa1024 (320, 2560)1024 (96.5, 2816)−0.3110.756
CSF white cell count (/mm3)a10 (43.75, 400.5)152 (40.5, 290)−0.2450.806
CSF protein at admission (g/L)a201.5 (96.75, 355.43)156 (91.6, 189)−1.0730.283
CSF protein max during hospitalization (g/L)a210.4 (130.5, 504)169.5 (91.6, 317)−1.4290.153
CSF lactate at admission (mmol/L)a28.6 (22.85, 52.175)18.1 (9.1, 24)−2.1970.028
CSF lactate max during hospitalization (mmol/L)a41.7 (29.9, 75.4)24 (20.1, 51.8)−2.0640.039
CSF glucose at admission (mmol/L)a45.5 (18.25, 58.75)36 (22, 49)−0.9760.329
CSF glucose max during hospitalization (mmol/L)a48 (30.5, 125.5)53 (25, 70)−0.5820.560
Serum sodium (mmol/L)138.90 ± 3.76137.86 ± 2.550.4460.516
Creatinine level at discharge (mol/L)1.0867 ± 0.271.22 ± 0.331.1250.312
Evan ratio in admission27.11 ± 3.0427.96 ± 5.340.0650.802
Evan ratio in follow-up27.13 ± 2.8626.12 ± 2.520.8770.365

Nonparametric independent samples test was used for the non-Gaussian distribution of data. Bold-faced values represent significant differences between groups ().