Long-Term Neuropsychological Sequelae in HIV-Seronegative Cryptococcal Meningoencephalitis Patients with and without Ventriculoperitoneal Shunts: A Cine MRI Study
Table 1
Demographic data of cryptococcal meningitis patients and controls.
Demographics
Patients with shunts
Patients without shunts
Normal
or
Gender (male/female)
9/1
7/1
28/4
0.022
0.978
Age at follow-up
53.70 ± 14.30
54.00 ± 9.87
51.47 ± 13.30
0.190
0.827
Education
9.30 ± 5.46
10.63 ± 4.63
12.56 ± 4.22
2.184
0.124
Duration of follow-up (months)a
73.5 (21.25, 113.25)
116 (38.5, 130.75)
—
−1.289
0.197
Hospitalization duration (days)a
53 (33.5, 60.5)
25 (17, 43)
—
−2.398
0.016
Glasgow Coma Scale at admissiona
15 (13.75, 15)
15 (14, 15)
—
−0.304
0.761
Glasgow Coma Scale at dischargea
15 (13.75, 15)
15 (15, 15)
—
−0.853
0.394
CSF Cryptococcal Ag titer at admissiona
1024 (320, 1536)
384 (96.5, 2816)
—
−0.842
0.400
Max CSF Cryptococcal Ag titer during hospitalizationa
1024 (320, 2560)
1024 (96.5, 2816)
—
−0.311
0.756
CSF white cell count (/mm3)a
10 (43.75, 400.5)
152 (40.5, 290)
—
−0.245
0.806
CSF protein at admission (g/L)a
201.5 (96.75, 355.43)
156 (91.6, 189)
—
−1.073
0.283
CSF protein max during hospitalization (g/L)a
210.4 (130.5, 504)
169.5 (91.6, 317)
—
−1.429
0.153
CSF lactate at admission (mmol/L)a
28.6 (22.85, 52.175)
18.1 (9.1, 24)
—
−2.197
0.028
CSF lactate max during hospitalization (mmol/L)a
41.7 (29.9, 75.4)
24 (20.1, 51.8)
—
−2.064
0.039
CSF glucose at admission (mmol/L)a
45.5 (18.25, 58.75)
36 (22, 49)
—
−0.976
0.329
CSF glucose max during hospitalization (mmol/L)a
48 (30.5, 125.5)
53 (25, 70)
—
−0.582
0.560
Serum sodium (mmol/L)
138.90 ± 3.76
137.86 ± 2.55
—
0.446
0.516
Creatinine level at discharge (mol/L)
1.0867 ± 0.27
1.22 ± 0.33
—
1.125
0.312
Evan ratio in admission
27.11 ± 3.04
27.96 ± 5.34
—
0.065
0.802
Evan ratio in follow-up
27.13 ± 2.86
26.12 ± 2.52
—
0.877
0.365
Nonparametric independent samples test was used for the non-Gaussian distribution of data. Bold-faced values represent significant differences between groups ().