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Behavioural Neurology
Volume 2015, Article ID 970204, 6 pages
http://dx.doi.org/10.1155/2015/970204
Research Article

Coexistence of Gait Disturbances and Chorea in Experimental Huntington’s Disease

1Department of Neuroscience, Maastricht University Medical Center, 6229 ER Maastricht, Netherlands
2European Graduate School of Neuroscience (EURON), 6229 ER Maastricht, Netherlands
3Department of Neurosurgery, Maastricht University Medical Center, 6229 ER Maastricht, Netherlands

Received 1 March 2015; Revised 6 April 2015; Accepted 17 April 2015

Academic Editor: Barbara Picconi

Copyright © 2015 João Casaca-Carreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Macdonald, “A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes,” Cell, vol. 72, no. 6, pp. 971–983, 1993. View at Publisher · View at Google Scholar
  2. R. I. Scahill, N. Z. Hobbs, M. J. Say et al., “Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy,” Human Brain Mapping, vol. 34, no. 3, pp. 519–529, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. M. A. Grimbergen, M. J. Knol, B. R. Bloem, B. P. H. Kremer, R. A. C. Roos, and M. Munneke, “Falls and gait disturbances in Huntington's disease,” Movement Disorders, vol. 23, no. 7, pp. 970–976, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. K. M. Biglan, C. A. Ross, D. R. Langbehn et al., “Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study,” Movement Disorders, vol. 24, no. 12, pp. 1763–1772, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. F. O. Walker, “Huntington's disease,” The Lancet, vol. 369, no. 9557, pp. 218–228, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. W. C. Koller and J. Trimble, “The gait abnormality of Huntington's disease,” Neurology, vol. 35, no. 10, pp. 1450–1454, 1985. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Delval, P. Krystkowiak, J.-L. Blatt et al., “Role of hypokinesia and bradykinesia in gait disturbances in Huntington's disease: a biomechanical study,” Journal of Neurology, vol. 253, no. 1, pp. 73–80, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Bilney, M. E. Morris, A. Churchyard, E. Chiu, and N. Georgiou-Karistianis, “Evidence for a disorder of locomotor timing in Huntington's disease,” Movement Disorders, vol. 20, no. 1, pp. 51–57, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. D. H. Zeef, A. Jahanshahi, R. Vlamings et al., “An experimental model for Huntington's chorea?” Behavioural Brain Research, vol. 262, pp. 31–34, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. N. C. Reynolds Jr., J. B. Myklebust, T. E. Prieto, and B. M. Myklebust, “Analysis of gait abnormalities in Huntington disease,” Archives of Physical Medicine and Rehabilitation, vol. 80, no. 1, pp. 59–65, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. S. J. Augood, R. L. M. Faull, and P. C. Emson, “Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease,” Annals of Neurology, vol. 42, no. 2, pp. 215–221, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Glass, M. Dragunow, and R. L. M. Faull, “The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease,” Neuroscience, vol. 97, no. 3, pp. 505–519, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Goto, A. Hirano, and R. R. Rojas-Corona, “Immunohistochemical visualization of afferent nerve terminals in human globus pallidus and its alteration in neostriatal neurodegenerative disorders,” Acta Neuropathologica, vol. 78, no. 5, pp. 543–550, 1989. View at Publisher · View at Google Scholar · View at Scopus
  14. E. K. Richfield, K. A. Maguire-Zeiss, C. Cox, J. Gilmore, and P. Voorn, “Reduced expression of preproenkephalin in striatal neurons from Huntington's disease patients,” Annals of Neurology, vol. 37, no. 3, pp. 335–343, 1995. View at Publisher · View at Google Scholar · View at Scopus
  15. E. K. Richfield, K. A. Maguire-Zeiss, H. E. Vonkeman, and P. Voorn, “Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients,” Annals of Neurology, vol. 38, no. 6, pp. 852–861, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. E. K. Richfield, C. F. O'Brien, T. Eskin, and I. Shoulson, “Heterogeneous dopamine receptor changes in early and late Huntington's disease,” Neuroscience Letters, vol. 132, no. 1, pp. 121–126, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. S. von Horsten, I. Schmitt, H. P. Nguyen et al., “Transgenic rat model of Huntington's disease,” Human Molecular Genetics, vol. 12, no. 6, pp. 617–624, 2003. View at Google Scholar
  18. J. C. Carreira, A. Jahanshahi, D. Zeef et al., “Transgenic rat models of Huntington's disease,” in Current Topics in Behavioral Neurosciences, Springer, Berlin, Germany, 2013. View at Publisher · View at Google Scholar
  19. R. Vlamings, D. H. Zeef, M. L. F. Janssen et al., “Lessons learned from the transgenic Huntington's disease rats,” Neural Plasticity, vol. 2012, Article ID 682712, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Cao, Y. Temel, A. Blokland et al., “Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel,” Behavioural Brain Research, vol. 170, no. 2, pp. 257–261, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Vandeputte, J.-M. Taymans, C. Casteels et al., “Automated quantitative gait analysis in animal models of movement disorders,” BMC Neuroscience, vol. 11, article 92, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. F. P. T. Hamers, A. J. Lankhorst, T. J. Van Laar, W. B. Veldhuis, and W. H. Gispen, “Automated quantitative gait analysis during overground locomotion in the rat: Its application to spinal cord contusion and transection injuries,” Journal of Neurotrauma, vol. 18, no. 2, pp. 187–201, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Yu-Taeger, E. Petrasch-Parwez, A. P. Osmand et al., “A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease,” Journal of Neuroscience, vol. 32, no. 44, pp. 15426–15438, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. J. E. Westin, M. L. F. Janssen, T. N. Sager, and Y. Temel, “Automated gait analysis in bilateral Parkinsonian rats and the role of L-DOPA therapy,” Behavioural Brain Research, vol. 226, no. 2, pp. 519–528, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. D. H. Zeef, R. Vlamings, L. W. Lim et al., “Motor and non-motor behaviour in experimental Huntington's disease,” Behavioural Brain Research, vol. 226, no. 2, pp. 435–439, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. F. P. T. Hamers, G. C. Koopmans, and E. A. J. Joosten, “CatWalk-assisted gait analysis in the assessment of spinal cord injury,” Journal of Neurotrauma, vol. 23, no. 3-4, pp. 537–548, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Vlamings, V. Visser-Vandewalle, G. Koopmans et al., “High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats,” Neuroscience, vol. 148, no. 3, pp. 815–823, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Jahanshahi, R. Vlamings, W. M. C. van Roon-Mom et al., “Changes in brainstem serotonergic and dopaminergic cell populations in experimental and clinical Huntington's disease,” Neuroscience, vol. 238, pp. 71–81, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Jahanshahi, R. Vlamings, A. H. Kaya et al., “Hyperdopaminergic status in experimental Huntington disease,” Journal of Neuropathology & Experimental Neurology, vol. 69, no. 9, pp. 910–917, 2010. View at Publisher · View at Google Scholar
  30. J. Collett, P. Esser, H. Khalil et al., “Insights into gait disorders: walking variability using phase plot analysis, Huntington's disease,” Gait & Posture, vol. 40, no. 4, pp. 694–700, 2014. View at Publisher · View at Google Scholar