The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants

Figure 4

Plot of performance (accuracy) and mean change in brain activity in response to high-loading WM task during fearful-face condition. The mean percent change in BOLD signal was extracted from voxels significantly different between groups (bilateral ACC and right MFG, white circle). Accuracy and reaction time were normalized by an arbitrary reference value of 100 and 1000, respectively, to allow a single plot of all three variables. Although accuracy and reaction time were relatively equivalent between groups, the MCI patients had relatively higher change in BOLD response compared to controls. Images are displayed in radiological convention, which means the right side of the image corresponds to the left side of the brain.

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