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Behavioural Neurology
Volume 2016 (2016), Article ID 3730940, 9 pages
Clinical Study

The Effect of Chronic Alprazolam Intake on Memory, Attention, and Psychomotor Performance in Healthy Human Male Volunteers

1Department of Pharmacy, University of Asia Pacific, Dhaka 1209, Bangladesh
2Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh
3Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh

Received 3 March 2016; Revised 12 May 2016; Accepted 7 June 2016

Academic Editor: João Quevedo

Copyright © 2016 Zahid Sadek Chowdhury et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Alprazolam is used as an anxiolytic drug for generalized anxiety disorder and it has been reported to produce sedation and anterograde amnesia. In the current study, the Cambridge Neuropsychological Test Automated Battery (CANTAB) software was used to test the effect of chronic intake of alprazolam in healthy volunteers. The selected testing battery consisted of the Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) tests for memory, Rapid Visual Information Processing (RVP) for attention, and Choice Reaction Time (CRT) for psychomotor performance. The testing was done twice: before starting the treatment and after the completion of the treatment. In the current investigation, statistically significant impairment of visual memory in one parameter of PAL and three parameters of DMS were found. However, one parameter of RVP was improved and no difference was observed in CRT.

  1. Supplementary Material