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Behavioural Neurology
Volume 2017, Article ID 5238402, 14 pages
Research Article

Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection

1Department of Molecular Immunology, City of Hope Beckman Research Institute, Duarte, CA, USA
2Department of Environmental Toxicology, UC Davis, Davis, CA, USA

Correspondence should be addressed to Edouard M. Cantin; gro.hoc@nitnace

Received 12 July 2017; Revised 6 September 2017; Accepted 16 September 2017; Published 19 November 2017

Academic Editor: Giuseppe Biagini

Copyright © 2017 Chandran Ramakrishna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. Representative FACS plots of brainstems isolated from the 3 groups of mice at day 21 pi showing mononuclear cells expressing (A) CD45high infiltrates, (B) CD11b+ monocytes, (C) Ly6C expressing IM, (D) HSV gB498 specific CD8 T cells showing reactivity for gB498-505 tetramer; (n=45 mice/group). Supplementary Figure 2. Serum cytokines and chemokines in the 3 groups of mice at day 7 pi. Sera from 4 mice / group were analyzed for G-CSF, CCL2, TNF and IL-23 by luminex multiplex assay. Supplementary Table 1: GO biological process categories enriched in serum proteins of HSV infected male and female mice.

  1. Supplementary material