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Behavioural Neurology
Volume 2017, Article ID 6137071, 6 pages
Research Article

Effect of Voluntary Wheel Running on Striatal Dopamine Level and Neurocognitive Behaviors after Molar Loss in Rats

1Capital University of Physical Education and Sports, Beijing 100191, China
2Beijing Xicheng District Desheng Community Health Service Center, Beijing 100120, China
3Peking University School and Hospital of Stomatology, Beijing 100081, China
4Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA

Correspondence should be addressed to Jianzhang Liu; nc.ude.umjb@gnahznaijuil and Kun Liu; ude.elay@uil.nuk

Linlin Zhang and Yi Feng contributed equally to this work.

Received 9 June 2017; Revised 25 August 2017; Accepted 2 October 2017; Published 5 December 2017

Academic Editor: Francesca Trojsi

Copyright © 2017 Linlin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of the present study is to evaluate the effect of voluntary wheel running on striatal dopamine level and behavior of cognition and emotion in molar loss rats. Twenty-four Sprague-Dawley rats were enrolled in this study and randomly divided into following 4 groups: control group (C group), molar loss group (ML group), 1-week physical exercise before molar loss group (1W-ML group), and 4-week physical exercise before molar loss group (4W-ML group). The rats both in 4W-ML and 1W-ML groups were placed in the voluntary running wheel in order to exercise for 4 weeks and 1 week, respectively. Then, the rats in 4W-ML, 1W-M, and ML groups received bilateral molar loss operation. After 10 days, striatal dopamine level was detected by in vivo microdialysis coupled with high-performance liquid chromatography (HPLC) and electrochemical detection. All the rats received behavior test after microdialysis detection. The behavior tests including passive avoidance test were used to assess cognition and elevated plus maze test for emotion. The results indicated that voluntary wheel running promoted striatal dopamine level in rats of molar loss. Behavioral data indicated that voluntary wheel running promoted cognition and emotion recovery after molar loss. Therefore, we concluded physical exercise significantly improved the neurocognitive behaviors and increased the striatal dopamine level after molar loss in rats.