| | Adverse effect | Comment |
| | Levetiracetam | Common:
Depression, hostility/aggression, anxiety, insomnia, nervousness/irritability
Uncommon:
Suicide attempt, suicidal ideation, psychotic disorder, abnormal behavior, hallucination, anger, confusion, panic attack, affect lability/mood swings, agitation
Rare:
Completed suicide, personality disorder, thinking abnormal | Higher prevalence in children and adolescents than in adults: agitation (3.4%), mood swings (2.1%), affect lability (1.7%), aggression (8.2%), abnormal behavior (5.6%) |
| | Perampanel | Common:
Aggression, anger, anxiety, confusion, irritability
Uncommon:
Suicidal ideation, suicide attempt | Aggression more frequently observed in adolescents than in adults |
| | Topiramate | Very common:
Depression
Common:
Irritability, bradyphrenia, insomnia, expressive language disorder, anxiety, confusion, disorientation, aggression, mood altered, agitation, mood swings, depressed mood, anger, abnormal behavior
Uncommon:
Suicidal ideation, suicide attempt, hallucination, psychotic disorder, hallucination auditory, hallucination visual, apathy, lack of spontaneous speech, sleep disorder, affect lability, libido decreased, restlessness, crying, dysphemia, euphoric mood, paranoia, perseveration, panic attack, tearfulness, reading disorder, initial insomnia, flat affect, thinking abnormal, loss of libido, listless, middle insomnia, distractibility, early morning awakening, panic reaction, elevated mood
Rare:
Mania, panic disorder, feeling of despair, hypomania | Irritability and expressive language among the most common adverse effects (>5%)
Higher prevalence in children than in adults (>2 times): suicidal ideation, abnormal behavior, aggression |
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