Research Article

Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies

Table 1

Characteristics of five included studies regarding antidepressants use and dementia risk.

Author/yearCountryStudy durationStudy designAdjustmentsResults

Wei-Sheng Lee-2016 [15]Taiwan2005–2011Case-control1, 2, 3, 4, 5, 6, 7, 8, 9For SSRIs,
(95% CI: 2.27–2.71)
For MAOIs,
(95% CI: 1.47–2.36)
For TCAs,
(95% CI: 1.32–1.57),
Wei-Sheng Lee-2017 [16]Taiwan2005–2011Case-control1, 2, 3, 4, 5, 6, 7, 8, 9For SSRIs,
(95% CI: 0.50–0.69)
For TCAs,
(95% CI: 0.89, 1.17
For NGAs,
(95% CI: 3.34, 5.37)
Wang 2016 [17]USA1991–2010Cohort1, 2, 3, 6, 9, 10 , 11, 12, 13, 14, 15, 16, 17, 18For SSRIs,
(95% CI)
For non-SSRIs,
(95% CI)
Then 2017 [18]Taiwan2003–2006Cohort1, 2, 3, 4, 8, 9, 19, 20For SSRIs,
(95% CI: 2.62–5.09)
For SNRI,
(95% CI: 2.54–8.80)
For TCAs,
(95% CI: 2.30–4.63)
For MAOIs,
(95% CI: 2.17–11.24)
Goveas 2012 [19]USA1996–2007Cohort1, 2, 3, 4, 6, 9, 10, 11, 21For SSRIs,
(95% CI: 1.01–3.10)
For TCAs,
(95% CI: 0.99–3.21).

(1) age, (2) gender, (3) diabetes, (4) hypertension, (5) stroke, (6) coronary artery disease, (7) head injury, (8) anxiety, (9) depression, (10) smoking, (11) body mass index, (12) cancer, (13) COPD, (14) liver disease, (15) hyperlipidemia, (16) renal disease, (17) thyroid disease, (18) cerebrovascular disease, (19) insomnia, (20) CCI, and (21) history of alcohol consumption.