Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats

Figure 7

Graphical representation of brain wet weight (a) and microphotographs of HE-stained sections (400x) of the hippocampal region of the brain (b) from different experimental rat groups in postmenopause-like conditions after 3 weeks of treatment. SHAM 1 = sham-operated rats treated with vehicle as normal control 1; SHAM 2 = sham-operated rats treated with vehicle as normal control 2; OVX = ovariectomized rats treated with vehicle as negative control; PIR = ovariectomized rats treated with piracetam at the dose of 1.5 mg/kg BW as positive control 1; E2V = ovariectomized rats treated with estradiol valerate at the dose of dose 1 mg/kg BW as positive control 2; FU 50 and 200 = ovariectomized rats treated with F. umbellata aqueous extract at the doses of 50 and 200 mg/kg BW, respectively; MC = ovariectomized rats treated with 7-methoxycoumarin at the dose of 1 mg/kg BW. Mi = microglia; Ne = neurons; Co = cortex. as compared to SHAM 2 group.

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