Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease
Table 1
Demographic and clinical characteristics of Parkinson’s disease patients with normal cognition, mild and major neurocognitive disorder.
Normal cognition ()
Mild neurocognitive disorder ()
Major neurocognitive disorder ()
Median
Percentile 25
Percentile 75
Mean
Standard deviation
Median
Percentile 25
Percentile 75
Mean
Standard deviation
Median
Percentile 25
Percentile 75
Mean
Standard deviation
value
Age
64
56
68
61.80
9.80
69
65
74
68.81
7.73
73
66
78
71.84
7.70
0.000
Education
13
11
16
13.63
2.98
12
11
13
11.97
2.85
11
8
12
11.01
3.39
0.000
Sex (M/F)a
157/120
94/71
66/44
0.82
Disease onset
57
48
64
55.36
11.55
61
53
69
61.21
10.73
65
56
74
63.73
12.22
0.000
Disease duration
5
2
9
6.36
6.04
6
2
11
7.57
6.28
6
2
13
8.06
7.06
0.04
MDS UPDRS part1
10
6
15
10.76
6.33
14
9
19
14.44
6.77
19
13
24
18.97
6.65
0.000
MDS UPDRS part2
10
5
17
11.17
7.60
14
9
20
14.75
7.72
20
12
27
19.61
8.82
0.000
MDS UPDRS part3
26
18
35
27.97
13.20
35
27
42
35.63
12.82
47
39
56
48.13
13.45
0.000
MDS UPDRS part4
4
1
5
3.89
3.20
4
2
6
4.30
3.33
4
4
6
5.11
3.27
0.003
Hoehn-Yahr stagea
2
2
2
2.25
.72
2
2
3
2.62
.85
3
3
4
3.27
.86
0.000
LED (mg)
480
150
920
616.29
582.09
680
200
1020
732.89
621.08
522
150
950
639.25
556.31
0.091
MADRS total score
8
4
13
8.8
6.3
12
7
17
12.7
6.9
17
12
20
17.0
6.6
0.000
MMSE total score
29
28
30
28.72
1.32
28
26
29
27.41
1.76
25
22
27
24.20
3.12
0.000
ACE-I total score
92
87
95
90.31
5.91
83
77
87
82.26
6.83
69
63
75
68.55
8.79
0.000
ACE-I orientation
10
10
10
9.92
.32
10
10
10
9.76
.63
10
9
10
9.05
1.46
0.000
ACE-I attention
8
8
8
7.83
.53
8
7
8
7.48
.95
7
5
8
6.33
1.73
0.000
ACE-I memory
31
28
33
30.33
4.05
27
22
30
25.96
4.99
19
16
24
19.62
5.39
0.000
ACE-I verbal fluency
11
9
12
10.39
2.05
9
7
10
8.38
2.34
6
4
7
5.53
2.41
0.000
ACE-I language
28
27
28
27.53
.76
27
27
28
27.04
1.11
26
25
27
25.65
1.94
0.000
ACE-I spatial visual
5
4
5
4.30
.90
4
3
5
3.65
1.13
2
1
3
2.37
1.31
0.000
ACE-III total score
91
86
95
90.08
6.00
83
77
87
81.92
6.48
68
60
76
66.99
9.91
0.000
ACE-III attention
18
17
18
17.37
1.02
17
16
18
16.63
1.47
14
13
17
14.55
2.46
0.000
ACE-III memory
23
21
25
22.56
3.15
20
17
22
19.44
3.99
14
12
18
14.45
4.53
0.000
ACE-III verbal fluency
11
9
12
10.36
2.09
9
7
10
8.42
2.31
5
4
7
5.40
2.44
0.000
ACE-III language
26
25
26
25.09
1.42
24
23
25
23.88
1.96
22
20
24
21.58
3.08
0.000
ACE-III spatial visual
15
14
16
14.69
1.52
14
12
15
13.55
1.88
11
9
13
11.01
2.73
0.000
Mini-ACE total score
27
25
29
26.4
2.9
23
20
25
22.4
3.4
16
13
19
15.8
4.3
0.000
ACE-I: Addenbrooke’s Cognitive Examination version I; ACE-III: Addenbrooke’s Cognitive Examination version III; Mini-ACE: Mini Addenbrooke’s Cognitive Examination; MMSE: Mini Mental State Examination; MDS UPDRS: Movement Disorders Society Unified Parkinson’s Disease Rating Scale (Pearson chi-square and Kendall-tau).
