Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease

Table 3

Diagnostic accuracy of ACE-I, ACE-III, Mini-ACE, and MMSE for detecting major neurocognitive disorder in the respect of education years.

Major neurocognitive disorder		Best cut-off score	Sensitivity	Specificity	Youden’s index	Positive likelihood ratio	Negative likelihood ratio	AUC area
ACE-I	0–8	74.5	0.821	0.744	0.565	3.207	0.241	0.871
	9–12	76.5	0.848	0.773	0.622	3.743	0.196	0.915
	>12	80.5	0.903	0.927	0.881	13.076	0.050	0.974
ACE-III	0–8	70.5	0.805	0.907	0.702	8.545	0.226	0.895
	9–12	77.5	0.909	0.740	0.649	3.497	0.123	0.926
	>12	78.5	0.957	0.927	0.894	12.439	0.100	0.972
Mini-ACE	0–8	17.5	0.718	0.791	0.509	3.430	0.357	0.833
	9–12	20.5	0.833	0.747	0.580	3.289	0.223	0.894
	>12	21.5	0.907	0.917	0.824	10.884	0.101	0.968
MMSE	0–8	25.5	0.744	0.860	0.604	5.329	0.298	0.866
	9–12	26.5	0.803	0.780	0.583	3.650	0.253	0.868
	>12	27.5	0.814	0.809	0.623	4.262	0.230	0.903