Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients

Table 1

Comparative analysis of baseline data for two groups: 134 cases with follow-up data compared to 160 cases without follow-up data.

Variable	Participants completing baseline and follow-up assessments (mean/SD)		Participants completing baseline assessment only (mean/SD)
Age	59.7 (10.1)	134	61.8 (9.9)	160	0.076
Onset to baseline assessment	14.3 (4.9)	134	12.8 (4.9)	160	0.012
Time from illness to enrollment	12.6 (4.4)	134	11.1 (4.3)	160	0.005
ALSFRS-R	38.5 (5.0)	129	34.2 (7.1)	154	<0.001
FVC	86.6 (20.5)	129	73.3 (22.4)	140	<0.001
% male	59.3	134	59	160	0.958
Race, % white	88.2	134	91.0	160	0.427
Hispanic ethnicity	9.3	134	4.5	160	0.108
Education		134		160
% HS/GED	26.7%		20.9%
Some college, AA	34.8%		29.1%
BA, BS, or higher	38.5%		50.0%		0.138
MMSE	29.1 (1.4)	120	28.8 (2.0)	132	0.121
CBS cognitive score	15.6 (2.8)	120	15.1 (3.3)	134	0.126
CBS behavioral score	37.4 (5.2)	118	34.7 (6.9)	131	0.036
FBI negative scale	3.2 (4.9)	119	4.0 (4.7)	132	0.119
FBI disinhibition scale	1.45 (2.56)	119	1.87 (2.31)	132	0.127
CNS-Lability Scale	12.2 (4.5)	130	13.7 (5.4)	158	0.009
COWAT total	36.7 (10.7)	64	33.3 (11.6)	80	0.076
VFI C words	13.8 (7.7)	77	11.3 (6.9)	52	0.177