The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease

Figure 2

The activation of the NLRP3 inflammasome through the RIP1-RIP3 signaling pathway. The activation of RIP1-RIP3 damages the mitochondria by activating the DRP1. This results in excessive production of ROS and subsequent trigger activation of the NLRP3 inflammasome. RIP3 also destructs lysosomal membrane stability, leading to hydrolase release (such as cathepsin-B) and activation of NLRP3-mediated inflammatory factors.