Research Article
Metabolic Risk Factors of Alzheimer’s Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study
Table 3
Multivariable analysis of risk of CAD and stroke in Cox proportional hazard regression.
| | Risk factors | All outcomes | CAD | Stroke | | Adjusted HR (95% CI) | Adjusted HR (95% CI) | Adjusted HR (95% CI) |
| | NC | 1 (reference) | 1 (reference) | 1 (reference) | | AD | 0.67 (0.59–0.76) | 0.59 (0.51–0.69) | 1.02 (0.8–1.3) | | DLB | 1.23 (1.06–1.44) | 1.04 (0.86–1.24) | 2.08 (1.58–2.73) | | Sex | | Female | 1 (reference) | 1 (reference) | 1 (reference) | | Male | 1.14 (1.06–1.23) | 1.11 (1.02–1.21) | 1.26 (1.07–1.49) | | Age, per year | 1.03 (1.03–1.04) | 1.03 (1.02–1.03) | 1.05 (1.04–1.06) | | Hypertension (yes versus no) | 1.39 (1.28–1.51) | 1.39 (1.27–1.53) | 1.37 (1.14–1.64) | | Diabetes mellitus (yes versus no) | 1.2 (1.09–1.34) | 1.15 (1.02–1.29) | 1.43 (1.15–1.78) | | Hyperlipidemia (yes versus no) | 0.9 (0.81–1) | 0.96 (0.86–1.09) | 0.7 (0.55–0.9) | | Aspirin (yes versus no) | 0.98 (0.89–1.09) | 0.95 (0.85–1.07) | 1.1 (0.89–1.37) | | Clopidogrel (yes versus no) | 1.25 (0.72–2.16) | 1.29 (0.69–2.41) | 1.14 (0.36–3.58) | | Warfarin (yes versus no) | 0.66 (0.38–1.13) | 0.6 (0.31–1.15) | 0.84 (0.31–2.27) |
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HR, hazard ratio; CI, confidence interval; NC, normal control; AD, Alzheimer’s disease; DLB, dementia with Lewy bodies. Adjusted sex, age, hypertension, diabetes mellitus, hyperlipidemia, aspirin, clopidogrel, and warfarin in Cox proportional hazards regression. , , and |
