Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice

Figure 1

The short- and long-term effects of traumatic brain injury (TBI) on Morris water maze performance in wild-type (WT) mice. (a) The escape latencies in TBI-treated (●, ) and sham-treated (○, ) WT mice during the training sessions of the hidden-platform task on day 1 (4 days after the injury) through day 4 of training. The probe trial (P) was performed 1 hour after the last trial of the training session on day 4. The visible platform version of the task (V) was carried out 4 days after the injury in an independent preliminary experiment. (b) The percentage of time spent in each quadrant (T: target quadrant; L: left quadrant; O: opposite quadrant; R: right quadrant) during the probe trial on day 4 (7 days after the injury). (c) The escape latencies in TBI (●, ) and sham-treated (○, ) WT mice during training sessions of the hidden-platform task on day 1 (25 days after the injury) through day 4. The probe trial (P) was performed 1 hour after the last trial of the training session on day 4. A visible platform version of the task (V) was carried out 32 days after the injury in an independent preliminary experiment. (d) The percentage of time spent in each quadrant during the probe trial on day 4 (28 days after the injury). , when compared with sham-treated WT mice.

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