The Effect of Metformin in Experimentally Induced Animal Models of Epileptic Seizure

Table 2

The quality assessment of individual study obtained according to the CAMARADES checklist items [39, 44].

References	Criteria
	I	II	III	IV	V	VI	VII	VIII	IX	X	Total (of 10)
Mehrabi et al. [40]	1	1	1	1	1	0	1	1	1	1	9
Zhao et al. [41]	1	1	1	1	1	0	1	1	1	1	9
Bibi et al. [43]	1	1	0	1	0	0	0	1	0	1	5
Sánchez-Elexpuru et al. [42]	1	1	1	1	0	0	0	0	0	1	5
Azeez [45]	1	1	1	1	1	0	1	1	0	1	8
Yang et al. [46]	1	1	1	1	1	0	1	1	0	1	8
Stone et al. [47]	1	1	0	1	1	0	1	0	0	1	6
Berthier et al. [48]	1	1	1	1	1	0	0	1	1	1	8
Chen et al. [49]	1	1	0	1	1	0	1	1	1	1	8
Hussein et al. [50]	1	1	1	1	1	0	1	1	1	1	8
Rubio Osornio et al. [51]	1	1	0	1	0	0	1	1	1	1	7
									Mean quality scores		(5 to 9)

(I) Publication in peer-reviewed journal, (II) number of experimental and control groups, (III) housing and husbandry conditions, (IV) details of intervention/exposure group procedures, (V) random allocation to groups, (VI) concealment of allocation, (VII) blinded assessment of outcomes, (VIII) biochemical evaluations, (IX) histopathological evaluations, and (X) statistical analysis. 1: criterion is satisfied, 0: the criterion is insufficiently described or not explained at all; the mean quality score is expressed as error of the mean (SEM) and (minimum and maximum score).