Review Article

Therapeutic Application of rTMS in Atypical Parkinsonian Disorders

Table 3

Studies assessing rTMS in CBD and LBD.

Author, yearType of studyStudy designResults

Shehata et al. [56]Prospective cohort study/open label(i) 26 CBS patients
(ii) Motor cortex contralateral to the more affected side
(iii) LF-rTMS (1 Hz, 90% of MT intensity), a session 3 times a week for 1 month, every 3 months
(iv) Assessment at baseline and every 3 months over 18 months via UPDRS, Addenbrooke’s cognitive examination (ACE-R), Unified Dystonia rating scale (UDRS), HRQoL, caregiver burden questionnaire and videotaping
(i) The UPDRS, caregiver burden, and quality of life were improved after 3 months
(ii) No adverse events
Takahashi et al. [58]Prospective cohort study/open label(i) 167 patients with mood disorder, 6 DLB patients received rTMS
(ii) DLPFC bilaterally
(iii) LF-rTMS (1 Hz, 110% of MT intensity) over the right DLPFC and HF-rTMS (10 Hz, 100% MT intensity) for the left DLPFC daily for ten days
(i) Assessment at baseline and after 10 days via the HAM-D
(i) Improvement of depressive symptoms
(ii) No adverse events