Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy

Figure 8

Photomicrographs of the hippocampus of albino rat group II (positive control group). The image shows the (a) CA1 and (b) CA3 areas of hippocampus proper and (c) dentate gyrus and shows CA1, CA3, and DG. An apparent decrease of the Nissl granules is seen in pyramidal and granule cells (↑) and ill-defined margins in CA1 and CA3 areas as compared to group I (negative control). In the CA3 area, wide inter cellular spaces are seen between pyramidal cells (). In DG, cells with deep basophilic cytoplasm (yellow arrow) are noticed. Scale bar: 50 μm, positive control group II, toluidine blue stain ×40.

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