Research Article

Synergistic Effects of Aldehyde Dehydrogenase 2 Polymorphisms and Alcohol Consumption on Cognitive Impairment after Ischemic Stroke in Han Chinese

Table 6

Multivariate odds ratios (95% confidence intervals)a for alcohol consumption on cognitive impairment in stroke patients, stratified by ALDH2 polymorphism.

ALDH2 genotypesAlcohol consumptionMethod 1Method 2

NondrinkersRefRef
Light drinkers1.75 (0.20-15.19)0.45 (0.05-3.91)
Moderate drinkers2.97 (0.60-14.68)2.43 (0.54-11.02)
Excessive drinkers7.75 (1.03-113.78)3.93 (0.84-18.44)

NondrinkersRefRef
Light drinkers15.99 (0.96-266.02)13.74 (1.96-96.51)#
Moderate drinkers10.95 (1.04-114.88)#22.36 (3.69-135.54)#
Excessive drinkers20.93 (2.77-158.45)#

Nondrinkers
Light drinkers
Moderate drinkers
Excessive drinkers

aModels were adjusted for age, gender, education, and subtype. vs. nondrinkers with ALDH2 wild-type genotype (). # vs. nondrinkers with ALDH2 mutant genotype ().