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Cerebral Edema and Behavioral Change: Mechanism Insights and Prospective

Call for Papers

Cerebral edema (CE) is a life-threatening condition that develops as a result of various forms of brain injury, such as cerebral trauma, ischemic and hemorrhagic stroke, and brain tumor and infection. Due to the rigidity of the skull, CE can lead to raised intracranial pressure (ICP), which subsequently decreases cerebral perfusion, ultimately leading to hypoxia, ischemia injury, and even herniation. Clinical complications of CE include behavioral and cognitive change, memory loss, mental dysfunctions, intracranial hypertension, seizures, and coma. The pathophysiology of CE is complex and multifactorial and can generally be categorized as vasogenic, cytotoxic, interstitial, or osmotic CE. Neuroimaging tools are useful to diagnose CE and its underlying effects on behavior, including computerized tomography, magnetic resonance imaging, and positron emission tomography. In addition, the aims for treatment of CE include avoidance of mechanical injury and hypoxia and maintenance of cerebral perfusion through drugs or surgery, to improve behavioral and cognitive outcome after brain injury.

This special issue is intended to discuss the pathophysiological changes, behavioral and cognitive deficits, and application of multimodality neuroimaging as well as impairment of brain structure and function after CE. Identification of biomarkers is of crucial importance to predict the behavioral and cognitive prognosis of patients with CE. We encourage investigators to submit original research articles and reviews to this special issue.

Potential topics include but are not limited to the following:

  • Genetic and physiopathology mechanisms and signaling pathways of CE
  • Behavioral and cognitive symptoms of CE
  • Neuroimaging correlates of behavioral and cognitive changes of CE
  • Potential management for behavioral and cognitive changes of CE
  • Biomarkers for behavioral and cognitive outcomes of CE

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 27 April 2018
Publication DateSeptember 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

Special Issue Editor in Chief

Guest Editors