Inhibition of Candida albicans by Fluvastatin Is Dependent on pH
Impact of Fluvastatin (FS) on survival and Fluconazole resistance of C. albicans. (a) Growth inhibition of clinical isolate 275G by FS. Squares, pH 4.5; Triangles, pH 7. Relative growth is given as OD620 treated/ OD620 untreated culture at the respective pH (4.5 or 7.0). At pH 4.5, FS causes growth inhibition at low concentrations. (b) FS, at low concentration/low pH, enhances the growth inhibition by fluconazole. Squares: strain 275G grown at pH 4.5 without FZ; triangles: same strain grown with 0.2 M FS.
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