Inhibition of Candida albicans by Fluvastatin Is Dependent on pH
Figure 1
Impact of Fluvastatin (FS) on survival and Fluconazole resistance of C. albicans. (a) Growth inhibition of clinical isolate 275G by FS. Squares, pH 4.5; Triangles, pH 7. Relative growth is given as OD620 treated/ OD620 untreated culture at the respective pH (4.5 or 7.0). At pH 4.5, FS causes growth inhibition at low concentrations. (b) FS, at low concentration/low pH, enhances the growth inhibition by fluconazole. Squares: strain 275G grown at pH 4.5 without FZ; triangles: same strain grown with 0.2 M FS.
