Inhibition of Candida albicans by Fluvastatin Is Dependent on pH
Impact of FS on stress response and HMG-CoA reductase activity in C. albicans. (a) Fluorescence and growth of CDR1 reporter strain CaSA1 in the presence of FS. Squares: Growth of CaSA1 relative to growth of FS-untreated cells. Triangles: Corresponding GFP fluorescence of samples. The intensity of GFP fluorescence is a measure of CDR1 expression and thus reflects the strength of the stress response. In the intermediate concentration range of 1–10 M that does not inhibit growth the cells do not exhibit signs of stress. (b) HMG-CoA reductase activity of strain ATCC10231 in arbitrary units. In the intermediate concentration range, HMG-CoA reductase is not as strongly inhibited as in the low range.
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