Matrix Metalloproteinases Contribute to Neuronal Dysfunction in Animal Models of Drug Dependence, Alzheimer's Disease, and Epilepsy

Table 6

Summary of changes in brain MMP expression levels and activities induced by chemical stimulants.

Drug	Dose (mg/kg)	Seizure intensity	MMP-2	MMP-9	Method (expression/activity)	References
Pentylene-tetrazole	40	Ear and facial twitching	±	±	Activity	[86]
	40	Kindled seizure (tonic convulsion)	±	⇑	Protein/activity	[86]
	60	Tonic convulsion	±	±	Activity	[86]
	50	Generalized seizures	N.D.	⇑	mRNA	[79]
Kainic acid	9-10	Tonic convulsion	N.D.	⇑	Protein/activity	[71, 83]
	10	Status epilepticus	N.D.	⇑	mRNA	[80]
	10	Convulsion	⇑	⇑	Activity	[82]
Pilocarpine	325	Status epilepticus	±	⇑	Protein/activity	[84]
Bicuculline	1.5–3.0	Convulsion	⇑	⇑	Activity	[82]

±: no change; ⇑: significant increase versus control mice; N.D.: not determined.