Review Article

Mitotic Kinases and p53 Signaling

Table 1

Mitotic kinases-mediated p53 phosphorylation and the possible consequences.

Mitotic kinasesPhosphorylation sitesOutcomeReferences

Aurora kinases
 Aurora ASer-215Inhibition of DNA binding and transcriptional activity[85]
Ser-315Protein destabilization[55]
 Aurora BSer-183Unknown [46]
Ser-269/Thr284Inhibition of transcriptional activity
 Aurora CUnknown

Polo-like kinases
 Plk1UnknownInhibition of transcriptional and proapoptotic activity[146]
 Plk2Unknown
 Plk3Ser-20Protein stabilization[169]
 Plk4UnknownPossibly affecting protein stabilization and transcriptional activation[178]
 Plk5Unknown

SAC kinases
 Bub1Ser-37Possibly inducing cellular senescence[193]
 Mps1Thr-18p53 stabilization [58]
p53-dependent postmitotic checkpoint activation
 BubR1Unknownp53 stabilization[59]