Biological Effects of Mammalian Translationally Controlled Tumor Protein (TCTP) on Cell Death, Proliferation, and Tumorigenesis

Figure 2

TCTP functions as an oncogene. NUMB forms a tricomplex with p53 and the E3 ubiquitin ligase MDM2, thereby preventing ubiquitination followed by degradation of p53. TCTP promotes p53 degradation by competing with NUMB for MDM2 binding. TCTP binds to Na, K-ATPase and, as a result, it releases Src binding to Na, K-ATPase and activate it. TCTP can release cofilin binding to G-actin by competing with and replacing cofilin. The increase of free cofilin then promotes the binding of the protein to F-actin and exerts its functions.