Figure 1: Schematic representation of the domain organization of human arrestins and arrestin-domain containing (ARRDC) proteins, and yeast ARTs (arrestin-related trafficking adaptors). Domains detected by Pfam 26.0 (http://pfam.sanger.ac.uk/) are shown and correspond to the following Pfam-A accessions: Arr_N: PF00339, Arr_C: PF02752, Arr_N-like (Ldb19): PF13002, along with the corresponding E-values for each domain (NA: not applicable; ND: not detected; NS: not significant). A putative Arr_N domain in Ecm21/Art2 was identified by alignment with the presumed Arr_N domain of Csr2/Art8. Clathrin-binding sites are depicted on 𝛽 -arrestins; potential binding sites for ubiquitin ligases of the Nedd4 family are also indicated on arrestin-related proteins.