Staurosporine Inhibits Frequency-Dependent Myofilament Desensitization in Intact Rabbit Cardiac Trabeculae
Figure 1
Panels (a), (b), and (c) show representative calcium transients (a), force tracings (b), and corresponding phase plane plots (c) from rabbit right ventricular trabeculae stimulated to contract at 1, 2, 3, and 4 Hz (37°C). Note the shift to the right of the relaxation trajectory of the phase plane plots. The same preparation was then treated with 100 nM staurosporine and the protocol repeated. Calcium transients (d), force tracings (e), and the resulting phase planes (f) are shown. Note the elimination of the relaxation trajectory shift after the addition of staurosporine.
